The goal of the Neurodegeneration Training Program (NTP) is to provide rigorous pre-doctoral training in various aspects of neurodegeneration and mechanisms of diseases involving neurodegeneration. An outstanding pool of trainees will combine with world-class faculty to investigate a wide range of neurodegeneration-related topics spanning research areas such as protein structure, cell and molecular biology and in vitro and in vivo models of disease. The NTP spans departments, schools and institutions to include multiple departments at Case Western Reserve University, particularly the School of Medicine, and its affiliated institutions, University Hospitals Case Medical Center (UHCMC), The Louis Stokes Cleveland Veteran's Administration Medical Center (VAMC), and the Cleveland Clinic Foundation (CCF, including the Lerner Research Institute). All of these institutions are within walking distance of each other and this rich training environment enjoys very active basic science and clinical activities and state of the art resources to enrich the training of pre- doctoal trainees as they engage in basic and/or translational research in the field of neurodegeneration. Training in the NTP involves NTP course work, formal and informal seminars, an annual retreat, and a research experience resulting in scholarly publications. A unique component of this training program is the inclusion of a required 1 semester, half day per week, mentored experience in a neurodegenerative disease clinic. The combination of didactic and experiential training opportunities afforded by the NTP will provide trainees a solid foundation for a future career in the scientific inquiry of neurodegeneration.

Public Health Relevance

The Neurodegeneration Training Program provides pre-doctoral training to produce future investigators who will drive important biomedical research efforts in neurodegeneration-related areas of clinical importance, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, Prion diseases, Multiple Sclerosis, stroke and other nervous system injury.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
4T32NS077888-04
Application #
9085404
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
2013-07-01
Project End
2018-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
4
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Benson, Bryan L; Li, Lucy; Myers, Jay T et al. (2018) Biomimetic post-capillary venule expansions for leukocyte adhesion studies. Sci Rep 8:9328
Babinchak, W Michael; Li, Zhenlu; Buck, Matthias (2018) Keys to Amyloid City: Computation and NMR Reveal Potential TDP-43 ALS Intermediates. Biophys J 115:1625-1627
Mlodzianoski, Michael J; Cheng-Hathaway, Paul J; Bemiller, Shane M et al. (2018) Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections. Nat Methods 15:583-586
Jiang, Sirui; Nandy, Priya; Wang, Wenzhang et al. (2018) Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex. Mol Neurodegener 13:5
Cheng-Hathaway, Paul J; Reed-Geaghan, Erin G; Jay, Taylor R et al. (2018) The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease. Mol Neurodegener 13:29
Niemi, Jon P; Filous, Angela R; DeFrancesco, Alicia et al. (2017) Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus. Exp Neurol 296:1-15
Rathkey, Joseph K; Benson, Bryan L; Chirieleison, Steven M et al. (2017) Live-cell visualization of gasdermin D-driven pyroptotic cell death. J Biol Chem 292:14649-14658
Wang, Wenzhang; Wang, Luwen; Lu, Junjie et al. (2016) The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity. Nat Med 22:869-78
Niemi, Jon P; DeFrancesco-Lisowitz, Alicia; Cregg, Jared M et al. (2016) Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism. Exp Neurol 275 Pt 1:25-37
Gorelenkova Miller, Olga; Behring, Jessica Belle; Siedlak, Sandra L et al. (2016) Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease. Antioxid Redox Signal 25:967-982

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