As our population ages, the incidence of Alzheimer disease (AD), Parkinson disease (PD), Amyotrophic lateral sclerosis (ALS) and other related neurodegenerative diseases continues to rise, and the need for successful translational research programs is imperative to maintain a healthy aging population and reduce the burden of increased health care costs on society. While much understanding of neurodegenerative mechanisms have been gained over the years of investigation, not much had been successfully translated into patient treatment which calls for deeper appreciation of these diseases through clinical perspective in the future neurodegeneration investigators. The Neurodegeneration Training Program (NTP) has been designed for selected students to provide rigorous pre-doctoral scientific training in the field of neurodegeneration along with extensive clinical exposure. The goal of the NTP is to provide trainees with the fundamental skills necessary for outstanding careers in neurodegeneration research, together with an appreciation of the challenges and complexity of diagnosing and treating neurodegenerative diseases in the clinical setting. The NTP emphasizes rigorous PHD training in fundamental aspects of neurodegeneration and mechanisms of diseases involving neurodegeneration and clinical perspectives through classroom teaching, neurodegeneration-related laboratory research and mentored neurodegenerative clinical experiences combined with educational forums that address important topics in clinical and translational neurodegeneration research. A competitive pool of trainees will combine with 19 outstanding faculty in state-of ?the-art facilities to investigate a wide range of neurodegeneration-related topics spanning research areas such as molecular genetics, protein structure, cell and molecular biology and in vitro and in vivo models of disease. The NTP promotes collaboration between departments and schools at Case Western Reserve University, particularly the School of Medicine, and with its affiliated institutions in the Cleveland area: University Hospitals Cleveland Medical Center (UHCMC), and the Cleveland Clinic Foundation (CCF, including the Lerner Research Institute). All of these institutions are within walking distance of each other and this rich training environment enjoys very active basic science and clinical activities. The updated curriculum provides a solid foundation for neurodegeneration research. The well-received mentored neurodegenerative clinical experience has been expanded to include six renowned clinicians enabling direct interaction with patients and caregivers in several different clinical centers close to CWRU campus providing motivation to the trainees to produce advances in disease diagnosis and therapies. The recently added career development and professional enrichment module ensures better preparedness of our trainees to achieve their desired career goals. Together, NTP training will provide trainees a solid foundation for an outstanding neurodegeneration-related career.
The Neurodegeneration Training Program provides training to outstanding predoctoral students to become leaders of academic, clinical, or pharmaceutical research programs focused on neurodegeneration. The program emphasizes rigorous basic neurodegeneration research, mentored clinical experience with patients, and career development skills necessary for making successful translational advances for maintaining a healthy aging population.
|Benson, Bryan L; Li, Lucy; Myers, Jay T et al. (2018) Biomimetic post-capillary venule expansions for leukocyte adhesion studies. Sci Rep 8:9328|
|Babinchak, W Michael; Li, Zhenlu; Buck, Matthias (2018) Keys to Amyloid City: Computation and NMR Reveal Potential TDP-43 ALS Intermediates. Biophys J 115:1625-1627|
|Mlodzianoski, Michael J; Cheng-Hathaway, Paul J; Bemiller, Shane M et al. (2018) Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections. Nat Methods 15:583-586|
|Jiang, Sirui; Nandy, Priya; Wang, Wenzhang et al. (2018) Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex. Mol Neurodegener 13:5|
|Cheng-Hathaway, Paul J; Reed-Geaghan, Erin G; Jay, Taylor R et al. (2018) The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease. Mol Neurodegener 13:29|
|Niemi, Jon P; Filous, Angela R; DeFrancesco, Alicia et al. (2017) Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus. Exp Neurol 296:1-15|
|Rathkey, Joseph K; Benson, Bryan L; Chirieleison, Steven M et al. (2017) Live-cell visualization of gasdermin D-driven pyroptotic cell death. J Biol Chem 292:14649-14658|
|Wang, Wenzhang; Wang, Luwen; Lu, Junjie et al. (2016) The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity. Nat Med 22:869-78|
|Niemi, Jon P; DeFrancesco-Lisowitz, Alicia; Cregg, Jared M et al. (2016) Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism. Exp Neurol 275 Pt 1:25-37|
|Gorelenkova Miller, Olga; Behring, Jessica Belle; Siedlak, Sandra L et al. (2016) Upregulation of Glutaredoxin-1 Activates Microglia and Promotes Neurodegeneration: Implications for Parkinson's Disease. Antioxid Redox Signal 25:967-982|
Showing the most recent 10 out of 16 publications