The Integrated Graduate Program in Neuroscience at the University of Texas Health Science Center at San Antonio (UTHSCSA) provides diverse training in a range of neuroscientific research areas and approaches, from molecular, cellular, and neurochemical to systems, behavioral and clinical neuroscience. There are 34 training faculty drawn from the mentoring faculty in the Neuroscience Track in the Integrated Multidisciplinary Graduate Program (IMGP) at UTHSCSA. This Neuroscience Training Program offers a course of study tailored to the individual needs and interests of students who come to us from a variety of backgrounds in the basic biological sciences, including biology, biochemistry, molecular biology, psychology and neuroscience. An interactive and collegial community of educators and researchers creates a challenging yet supportive environment within which our students can develop into successful neuroscientists. Students apply to and enter a single integrated """"""""umbrella"""""""" graduate program, the IMGP, within which there are 10 thematically- defined """"""""tracks"""""""", of which Neuroscience is one, that cut across departments and schools within the university. Thus, in their first year of study in the IMGP, students take a common core course in Biomedical Sciences and conduct a series of lab rotations. In the spring, they begin to differentiate and take courses specific to their area of interest, in our cas Neuroscience. They then select a mentor and a track, and begin their focused training. In the second year of study, we offer the Neuroscience students a rich curriculum of didactic courses, intensive laboratory experience, opportunities for professional development (writing and oral presentation), journal clubs, seminars, opportunities to engage in relevant clinical activities, an several other enrichment activities designed to enhance their professional development and future success. The institution supports the students in the first year. Thus, we are requesting funds for 3 students per year, for only one year each, in the second year of study, during which they focus on Neuroscience course work, intensify their laboratory research toward identifying a dissertation project, and prepare for their qualifying exam at the end of this second year, after which they enter doctoral candidacy and begin their dissertation research. One or more of these slots may be used to support MD/PhD student(s) at the equivalent stage of the graduate component of their training in the Neuroscience program. Strategies are described for recruitment, including recruitment for diversity, and for training in the responsible conduct of research. In sum, since its inception just 10 years ago, the Neuroscience Program at the UTHSCSA has emerged into a mature and effective program, one of the most popular in the Graduate School, with a productive and dedicated training faculty, a robust curriculum, and a well-functioning administrative structure. If funded, this broadly-based early-stage training grant will not only facilitate our further development and growth, it will also allow us the opportunity o offer a substantive return on that investment, by continuing on the forward and upward trajectory of both our program and our students.

Public Health Relevance

The Integrated Graduate Program in Neuroscience at the University of Texas Health Science Center at San Antonio provides training in areas of expertise that range from molecular to behavioral neuroscience, in a biomedical environment that fosters a unique interaction with and exposure to clinical and translational neuroscience. We offer a program of coursework, mentored laboratory research, and professional enrichment activities tailored to the individual interests and needs of our students, with particular opportunities for motivated and talented students from the under-represented population in the South Texas region served by our institution, while maintaining competitiveness on a national scale. Funding of this training grant will enhance the development of our students into successful neuroscientists, equipped to address the challenges of the future, and to train the next generation of neuroscientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Institutional National Research Service Award (T32)
Project #
1T32NS082145-01A1
Application #
8473614
Study Section
Special Emphasis Panel (ZNS1-SRB-P (69))
Program Officer
Korn, Stephen J
Project Start
2013-07-01
Project End
2018-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$64,293
Indirect Cost
$4,317
Name
University of Texas Health Science Center San Antonio
Department
Pharmacology
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Fucich, Elizabeth A; Morilak, David A (2018) Shock-probe Defensive Burying Test to Measure Active versus Passive Coping Style in Response to an Aversive Stimulus in Rats. Bio Protoc 8:
Girotti, Milena; Adler, Samantha M; Bulin, Sarah E et al. (2018) Prefrontal cortex executive processes affected by stress in health and disease. Prog Neuropsychopharmacol Biol Psychiatry 85:161-179
Garrison, Allison M; Parrott, Jennifer M; Tuñon, Arnulfo et al. (2018) Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation. Psychoneuroendocrinology 94:1-10
Jacobs, Blaine A; Pando, Miryam M; Jennings, Elaine et al. (2018) Allosterism within ? Opioid-? Opioid Receptor Heteromers in Peripheral Sensory Neurons: Regulation of ? Opioid Agonist Efficacy. Mol Pharmacol 93:376-386
Fucich, Elizabeth A; Paredes, Denisse; Saunders, Madeleine O et al. (2018) Activity in the Ventral Medial Prefrontal Cortex Is Necessary for the Therapeutic Effects of Extinction in Rats. J Neurosci 38:1408-1417
Ye, Liang; Haroon, Mateen A; Salinas, Angelica et al. (2017) Comparison of GCaMP3 and GCaMP6f for studying astrocyte Ca2+ dynamics in the awake mouse brain. PLoS One 12:e0181113
Sullivan, Laura C; Chavera, Teresa A; Gao, Xiaoli et al. (2017) Regulation of ? Opioid Receptor-Mediated Signaling and Antinociception in Peripheral Sensory Neurons by Arachidonic Acid-Dependent 12/15-Lipoxygenase Metabolites. J Pharmacol Exp Ther 362:200-209
Avelar, Alicia J; Cao, Jianjing; Newman, Amy Hauck et al. (2017) Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons. Neuropharmacology 123:410-419
Fucich, Elizabeth A; Paredes, Denisse; Morilak, David A (2016) Therapeutic Effects of Extinction Learning as a Model of Exposure Therapy in Rats. Neuropsychopharmacology 41:3092-3102
Solano Fonseca, Rene; Mahesula, Swetha; Apple, Deana M et al. (2016) Neurogenic Niche Microglia Undergo Positional Remodeling and Progressive Activation Contributing to Age-Associated Reductions in Neurogenesis. Stem Cells Dev 25:542-55

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