The OSU Mouse Pathobiology training program is a four-year program designed to produce veterinary scientists capable of conducting independent and collaborative research using mouse models of human disease. Trainees will be selected from motivated and talented D.V.M. or D.V.M., Ph.D. candidates who are committed to careers in research. Trainees will complete one year of specialty education in veterinary pathology, clinical pathology, microbiology, or laboratory animal medicine that will include a three month rotation through the Laboratory Animal Program. The first year will be funded by the Department of Veterinary Biosciences. Then the T32 training program will require three years during which trainees will complete independent research projects within a training faculty's laboratory. Trainees without a Ph.D. degree will pursue a Ph.D. in Comparative and Experimental Pathobiology in the Department of Veterinary Biosciences. The research projects will focus on using mouse models to investigate the pathophysiology of significant human diseases. The training faculty (24 members) have focused research excellence in comparative cancer medicine, infectious diseases, immunology, and development of genetically altered mouse models of human disease. All training faculty use experimental mouse models of human disease in their work. The 24 training faculty represent a diverse spectrum of investigators in veterinary biosciences, internal medicine, medical biochemistry and physiology, cancer genetics, mouse genetics, surgery, molecular biology, and oral biology that have developed a network of collaborative interactions within The Ohio State University Health Sciences Center (consisting of seven colleges). The training faculty represent the Colleges of Veterinary Medicine, Medicine, Biologic Sciences, and Dentistry. The OSU Comprehensive Cancer Center (including its core services), James Cancer Hospital and Solove Research Institute, and transgenic cores of the Neurobiotechnology Center and Children's Hospital are organizations at the OSU that will facilitate the research programs and training faculty interaction. Selected formal courses will be chosen for trainees based on their needs and goals. Completion of the program will enable trainees to develop the skills necessary to design and conduct in vivo experiments and serve as resource persons in academic or industrial institutions to facilitate research projects using mouse models of human disease.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Institutional National Research Service Award (T32)
Project #
5T32RR007073-04
Application #
6895224
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Watson, William T
Project Start
2002-06-01
Project End
2007-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
4
Fiscal Year
2005
Total Cost
$319,417
Indirect Cost
Name
Ohio State University
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
832127323
City
Columbus
State
OH
Country
United States
Zip Code
43210
Berman-Booty, Lisa D; Thomas-Ahner, Jennifer M; Bolon, Brad et al. (2015) Extra-prostatic transgene-associated neoplastic lesions in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice. Toxicol Pathol 43:186-97
Grieves, Jessica L; Yin, Zhiwei; Durbin, Russell K et al. (2015) Acute and Chronic Airway Disease After Human Respiratory Syncytial Virus Infection in Cotton Rats (Sigmodon hispidus). Comp Med 65:315-26
Berman-Booty, Lisa D; Chu, Po-Chen; Thomas-Ahner, Jennifer M et al. (2013) Suppression of prostate epithelial proliferation and intraprostatic progrowth signaling in transgenic mice by a new energy restriction-mimetic agent. Cancer Prev Res (Phila) 6:232-41
Wancket, Lyn M; Meng, Xiaomei; Rogers, Lynette K et al. (2012) Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury. Toxicol Pathol 40:1095-105
Shu, Sherry T; Dirksen, Wessel P; Lanigan, Lisa G et al. (2012) Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1? in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro. Leuk Lymphoma 53:688-98
Beamer, Gillian L; Cyktor, Joshua; Flaherty, David K et al. (2012) CBA/J mice generate protective immunity to soluble Ag85 but fail to respond efficiently to Ag85 during natural Mycobacterium tuberculosis infection. Eur J Immunol 42:870-9
Berman-Booty, Lisa D; Sargeant, Aaron M; Rosol, Thomas J et al. (2012) A review of the existing grading schemes and a proposal for a modified grading scheme for prostatic lesions in TRAMP mice. Toxicol Pathol 40:5-17
Wancket, Lyn M; Frazier, W Joshua; Liu, Yusen (2012) Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease. Life Sci 90:237-48
Beamer, Gillian L; Cyktor, Joshua; Carruthers, Bridget et al. (2011) H-2 alleles contribute to antigen 85-specific interferon-gamma responses during Mycobacterium tuberculosis infection. Cell Immunol 271:53-61
Vesosky, Bridget; Rottinghaus, Erin K; Stromberg, Paul et al. (2010) CCL5 participates in early protection against Mycobacterium tuberculosis. J Leukoc Biol 87:1153-65

Showing the most recent 10 out of 35 publications