In this competitive renewal proposal, we seek funds to continue to provide an outstanding environment for veterinarians (D.V.M. or V.M.D.) and D.V.M./PhDs to attain specific research and conceptual skills to develop and utilize mouse models of human disease. The training program has been highly successful in establishing the program exceeding all goals of the original proposed plan. Despite having training positions cut by NCRR the program has enrolled 11 DVMs. Of the 11 trainees supported over the first 4.5 years of the program, two were awarded NIH K Awards (K08 and K01), two have matriculated and are employed in biomedical or academic positions, and 9 are completing requirements for their Ph.D. degrees of which 5 currently are funded by the T-32 training grant. All veterinarians recruited into the program have outstanding academic records and we have added new experienced training faculty. Training courses, seminars, and workshops have created specialized and focused training opportunities. Specifically, veterinarian scientists will continue to be trained in state-of-the-art techniques to systematically evaluate the pathobiology of mouse models of human disease. The training program will be coordinated through an established graduate program in the College of Veterinary Medicine and supported by a unified group of basic and clinical scientists with ongoing collaborative programs at The Ohio State University and Children's Hospital in Columbus, Ohio. Trainees will gain knowledge and skills to fully understand and evaluate pathophysiologic alterations of murine models of human disease through both didactic coursework and applied training in pathology and molecular biology. In addition, trainees will interact with our multidisciplinary faculty to identify the range of research problems that use murine models. They will acquaint themselves with the ongoing basic and clinical research studies in the laboratories of the participating faculty, and select a research problem that utilizes a murine model for endpoint evaluation. Following the selection of a preceptor and research problem, the trainee will participate in the design and performance of experiments, as well as analysis and presentation of data regarding a murine model. Therefore, trainees will acquire a broad background in molecular biology, genetics, pathology, laboratory animal medicine, as well as research design methodology, to provide trainees the skills needed to work in research teams to fulfill national needs in the development of skilled scientists in mouse pathobiology.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Watson, William T
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Ohio State University
Veterinary Sciences
Schools of Veterinary Medicine
United States
Zip Code
Grieves, Jessica L; Yin, Zhiwei; Durbin, Russell K et al. (2015) Acute and Chronic Airway Disease After Human Respiratory Syncytial Virus Infection in Cotton Rats (Sigmodon hispidus). Comp Med 65:315-26
Berman-Booty, Lisa D; Thomas-Ahner, Jennifer M; Bolon, Brad et al. (2015) Extra-prostatic transgene-associated neoplastic lesions in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice. Toxicol Pathol 43:186-97
Berman-Booty, Lisa D; Chu, Po-Chen; Thomas-Ahner, Jennifer M et al. (2013) Suppression of prostate epithelial proliferation and intraprostatic progrowth signaling in transgenic mice by a new energy restriction-mimetic agent. Cancer Prev Res (Phila) 6:232-41
Wancket, Lyn M; Meng, Xiaomei; Rogers, Lynette K et al. (2012) Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury. Toxicol Pathol 40:1095-105
Shu, Sherry T; Dirksen, Wessel P; Lanigan, Lisa G et al. (2012) Effects of parathyroid hormone-related protein and macrophage inflammatory protein-1? in Jurkat T-cells on tumor formation in vivo and expression of apoptosis regulatory genes in vitro. Leuk Lymphoma 53:688-98
Beamer, Gillian L; Cyktor, Joshua; Flaherty, David K et al. (2012) CBA/J mice generate protective immunity to soluble Ag85 but fail to respond efficiently to Ag85 during natural Mycobacterium tuberculosis infection. Eur J Immunol 42:870-9
Berman-Booty, Lisa D; Sargeant, Aaron M; Rosol, Thomas J et al. (2012) A review of the existing grading schemes and a proposal for a modified grading scheme for prostatic lesions in TRAMP mice. Toxicol Pathol 40:5-17
Wancket, Lyn M; Frazier, W Joshua; Liu, Yusen (2012) Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology, and disease. Life Sci 90:237-48
Beamer, Gillian L; Cyktor, Joshua; Carruthers, Bridget et al. (2011) H-2 alleles contribute to antigen 85-specific interferon-gamma responses during Mycobacterium tuberculosis infection. Cell Immunol 271:53-61
Vesosky, Bridget; Rottinghaus, Erin K; Stromberg, Paul et al. (2010) CCL5 participates in early protection against Mycobacterium tuberculosis. J Leukoc Biol 87:1153-65

Showing the most recent 10 out of 35 publications