This application requests support for an interdepartmental training program in Infectious Diseases and Inflammatory Disorders and is designed to promote the entry of outstanding medical students into biomedical research careers. This innovative research enrichment program combines the mentoring faculty's research expertise with unique institutional resources for the hands-on training of medical students. Training is provided by 28 program faculty members from the Departments of Microbiology &Immunology, Biochemistry &Molecular Biology, Pathology, Internal Medicine, Pediatrics, and Surgery. The research theme will be centered on infections and inflammation, especially in terms of transmission of pathogens, regulation of host inflammatory responses at the sites of pathogen entry (airway, skin, and mucosa), regulation of leukocyte migration in the blood, liver and other organs, and vaccine/drug development for the control of pathogens and tissue damage. Trainees will work in full-time positions during a 12-week research period, and receive an in-depth exposure to biological concepts and modern biomedical research areas and tools. They will also have the opportunity to choose basic, clinical, and translational or behavior research projects. The program will match talented medical students with NIH-funded research faculty mentors, coupling the daily research experience with an ongoing series of courses, summer research seminars, peer round-table research discussions, oral presentations, and monitoring from outstanding UTMB faculty. The specific objectives are: 1) to expose medical students early in their career development to the excitement and challenges of a research career and to encourage their investigative and analytical skills, 2) to encourage medical students to pursue a career in basic and clinical research in the areas of infectious diseases and inflammatory disorders, 3) to provide valuable experience and potential references for students who wish to seek additional research training and funding in the future, and 4) to increase the pool of physician scientists engaged in biomedical or behavioral research in those areas necessary for the mission of the NIAID. Opportunities exist for formal presentation of research findings during national symposia and meetings, and an adequate tracking system is in place for monitoring career development of trainees and success of this training program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
NRSA Short -Term Research Training (T35)
Project #
5T35AI078878-02
Application #
7623867
Study Section
Allergy & Clinical Immunology-1 (AITC)
Program Officer
Prograis, Lawrence J
Project Start
2008-06-01
Project End
2013-05-31
Budget Start
2009-06-01
Budget End
2010-05-31
Support Year
2
Fiscal Year
2009
Total Cost
$40,785
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Gupta, Akshaya; Yo, Jacob; Huang, Gengming et al. (2018) Developmental Defects Associated With DNA Copy Number Gain of Chromosome 2q33.1: A Case Report and Review of Literature. Lab Med 49:160-164
Liang, Yuejin; Yi, Panpan; Yuan, Denley Ming Kee et al. (2018) IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis. Cell Mol Immunol :
Soong, Lynn; Shelite, Thomas R; Xing, Yan et al. (2017) Type 1-skewed neuroinflammation and vascular damage associated with Orientia tsutsugamushi infection in mice. PLoS Negl Trop Dis 11:e0005765
Yi, Panpan; Liang, Yuejin; Yuan, Denley Ming Kee et al. (2017) A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection. Sci Rep 7:3857
Zhu, Shuang; Luo, Huanle; Liu, Hua et al. (2017) p38MAPK plays a critical role in induction of a pro-inflammatory phenotype of retinal Müller cells following Zika virus infection. Antiviral Res 145:70-81
Soong, Lynn; Mendell, Nicole L; Olano, Juan P et al. (2016) An Intradermal Inoculation Mouse Model for Immunological Investigations of Acute Scrub Typhus and Persistent Infection. PLoS Negl Trop Dis 10:e0004884
Grimes, Logan; Doyle, Allie; Miller, Aaron L et al. (2016) Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury. PLoS One 11:e0166770
Liang, Yuejin; Jie, Zuliang; Hou, Lifei et al. (2015) IL-33 promotes innate IFN-? production and modulates dendritic cell response in LCMV-induced hepatitis in mice. Eur J Immunol 45:3052-63
Gupta, Shivali; Silva, Trevor S; Osizugbo, Jessica E et al. (2014) Serum-mediated activation of macrophages reflects TcVac2 vaccine efficacy against Chagas disease. Infect Immun 82:1382-9
Gupta, Shivali; Wan, Xianxiu; Zago, Maria P et al. (2013) Antigenicity and diagnostic potential of vaccine candidates in human Chagas disease. PLoS Negl Trop Dis 7:e2018

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