Boston's Fenway Community Heath Center (FCHC), in collaboration with Brown University in Providence, RI, is applying to become an HIV Prevention Trials Unit (HPTU), building on longstanding successful collaborations as the New England HIVNET unit. The clinical sites for this HPTU will include a) FCHC; b) Brown University, including its teaching hospitals, the Memorial, Miriam, and Women and Infants Hospitals; and c) Brown's Fogarty AIDS International Training and Research Program affiliate in Chennai, India, an NGO, YR Gaitonde Center for AIDS Research and Education (YRGCare). The HPTU will actively participate with the Scientific Leadership Group development, implementation and recruitment for the following studies to: I) enroll 50 HIV(-)low risk women, 15-20 of their HIV(-)low risk male partners, and 20 HIV-infected women in 3 different Phase I vaginal microbicide studies; 2) enroll 100 HIV(-) high risk women in Rhode Island and 100 HIV(-) high risk women in Chennai in a Phase IIB microbicide screening trial; 3) continue to follow the 720 men recruited at FCHC into explore!, the behavioral intervention for MSMs; 4) enroll 500 HIV(-) high risk women in a Phase IIB behavioral intervention; 4) enroll 30 couples (heterosexual or MSM) to study the effects of antiretroviral therapy on genital tract HIV and transmission dynamics; 5) enroll 50 active IDUs from Rhode Island in Phase I studies to assess strategies that-will alter needle sharing behavior, and; 6) enroll 50 HIV-infected pregnant women in year I and 100 mother/infant pairs in each of the following years in Chennai in a multicenter study of newer antiretroviral regimens designed to interrupt perinatal transmission. Additionally, we will participate in the STD Scientific Working Group to develop new protocols relevant to the populations studied in each of the major participating sites of our consortium. We will continue our leadership work in community education and the engagement of diverse communities in HIV prevention initiatives.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01AI048040-01
Application #
6190143
Study Section
Special Emphasis Panel (ZAI1-KWR-A (M1))
Program Officer
Gross, Michael
Project Start
2000-07-01
Project End
2005-06-30
Budget Start
2000-07-01
Budget End
2001-06-30
Support Year
1
Fiscal Year
2000
Total Cost
$1,300,001
Indirect Cost
Name
Fenway Community Health Center
Department
Type
DUNS #
072366156
City
Boston
State
MA
Country
United States
Zip Code
02215
Mimiaga, Matthew J; O?Cleirigh, Conall; Biello, Katie B et al. (2015) The effect of psychosocial syndemic production on 4-year HIV incidence and risk behavior in a large cohort of sexually active men who have sex with men. J Acquir Immune Defic Syndr 68:329-36
Marshall, Brandon D L; Shoveller, Jean A; Kahler, Christopher W et al. (2015) Heavy drinking trajectories among men who have sex with men: a longitudinal, group-based analysis. Alcohol Clin Exp Res 39:380-9
Koblin, Beryl A; Mansergh, Gordon; Chesney, Margaret et al. (2014) Moving the bar to the right place: positioning interventions in HIV prevention. AIDS Behav 18:634-7
Tieu, Hong-Van; Li, Xin; Donnell, Deborah et al. (2013) Anal sex role segregation and versatility among men who have sex with men: EXPLORE Study. J Acquir Immune Defic Syndr 64:121-5
Bedoya, C Andres; Mimiaga, Mathew J; Beauchamp, Geetha et al. (2012) Predictors of HIV transmission risk behavior and seroconversion among Latino men who have sex with men in Project EXPLORE. AIDS Behav 16:608-17
Hoffman, Susie; Morrow, Kate M; Mantell, Joanne E et al. (2010) Covert use, vaginal lubrication, and sexual pleasure: a qualitative study of urban U.S. Women in a vaginal microbicide clinical trial. Arch Sex Behav 39:748-60
Donnell, Deborah; Mimiaga, Matthew J; Mayer, Kenneth et al. (2010) Use of non-occupational post-exposure prophylaxis does not lead to an increase in high risk sex behaviors in men who have sex with men participating in the EXPLORE trial. AIDS Behav 14:1182-9
Barresi, Patrick; Husnik, Marla; Camacho, Michael et al. (2010) Recruitment of men who have sex with men for large HIV intervention trials: analysis of the EXPLORE Study recruitment effort. AIDS Educ Prev 22:28-36
Chin-Hong, Peter V; Husnik, Marla; Cranston, Ross D et al. (2009) Anal human papillomavirus infection is associated with HIV acquisition in men who have sex with men. AIDS 23:1135-42
Mimiaga, Matthew J; Noonan, Elizabeth; Donnell, Deborah et al. (2009) Childhood sexual abuse is highly associated with HIV risk-taking behavior and infection among MSM in the EXPLORE Study. J Acquir Immune Defic Syndr 51:340-8

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