Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA040884-04
Application #
3548703
Study Section
(SRC)
Project Start
1985-07-01
Project End
1988-07-31
Budget Start
1988-07-01
Budget End
1988-07-31
Support Year
4
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Florida
Department
Type
Schools of Medicine
DUNS #
073130411
City
Gainesville
State
FL
Country
United States
Zip Code
32611

  Publications

Chen, A Y; Liu, L F (1994) DNA topoisomerases: essential enzymes and lethal targets. Annu Rev Pharmacol Toxicol 34:191-218
Tsao, Y P; Russo, A; Nyamuswa, G et al. (1993) Interaction between replication forks and topoisomerase I-DNA cleavable complexes: studies in a cell-free SV40 DNA replication system. Cancer Res 53:5908-14
Woessner, R D; Eng, W K; Hofmann, G A et al. (1992) Camptothecin hyper-resistant P388 cells: drug-dependent reduction in topoisomerase I content. Oncol Res 4:481-8
Mattern, M R; Hofmann, G A; McCabe, F L et al. (1991) Synergistic cell killing by ionizing radiation and topoisomerase I inhibitor topotecan (SK&F 104864). Cancer Res 51:5813-6
Mattern, M R; Nambi, P; Bartus, J O et al. (1991) Regulation of topoisomerase I and II activities by cyclic nucleotide- and phospholipid-dependent protein kinases. Effects of interactions between the two transduction pathways. Receptor 1:181-90
Woessner, R D; Mattern, M R; Mirabelli, C K et al. (1991) Proliferation- and cell cycle-dependent differences in expression of the 170 kilodalton and 180 kilodalton forms of topoisomerase II in NIH-3T3 cells. Cell Growth Differ 2:209-14
Kingsbury, W D; Boehm, J C; Jakas, D R et al. (1991) Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity. J Med Chem 34:98-107
Woessner, R D; Chung, T D; Hofmann, G A et al. (1990) Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II. Cancer Res 50:2901-8
Hertzberg, R P; Busby, R W; Caranfa, M J et al. (1990) Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site. J Biol Chem 265:19287-95
Hofmann, G A; Mirabelli, C K; Drake, F H (1990) Quantitative adaptation of the bacteriophage P4 DNA unknotting assay for use in the biochemical and pharmacological characterization of topoisomerase II. Anticancer Drug Des 5:273-82

Showing the most recent 10 out of 41 publications