Colorectal cancer (CRC) is still the second most common cause of cancer death in the United States, despite the availability of a range of interventions to reduce the burden of CRC. Microsimulation modeling can inform policy makers in prioritizing among these cancer-control interventions. The CISNET-CRC team includes three collaborative modeling groups, each with a state-of-the-art, population-based microsimulation model for CRC: MISCAN, SimCRC, and CRC-SPIN. These three modeling groups have collaborated for eight years and have delivered a substantial body of policy-oriented work. We propose to continue this collaboration, further developing our models and using them to identify optimal cancer-control policies and practices to reduce the burden of CRC. Our proposed work centers around three specific aims.
In Aim 1 we extend our models to reflect the evolving understanding of the CRC disease processes and to incorporate new and updated screening modalities, allowing us to address new policy questions. Here we focus on new data on genomics, biomarkers, pathways, and the upcoming data from randomized controlled trials of flexible sigmoidoscopy screening.
In Aim 2 we apply our updated models to inform health policy, including evaluation of interventions across the cancer-control spectrum. New technologies and more individually tailored screening and treatment strategies will be evaluated with a special focus on health disparities.
In Aim 3 we disseminate results from our models to inform health policy, via methods that engage policy makers and encourage appropriate use of modeling in policy making and decision support. Here we envision innovation using open-access web-based model applications. We will begin with model extensions required for specific applications, with the balance of the work shifting heavily toward applications over the course of the funding period. Dissemination of our findings will occur throughout the funding period.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01CA152959-03
Application #
8331237
Study Section
Special Emphasis Panel (ZCA1-SRLB-4 (M1))
Program Officer
Stedman, Margaret R
Project Start
2010-09-01
Project End
2015-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
3
Fiscal Year
2012
Total Cost
$1,043,795
Indirect Cost
$67,822
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Lansdorp-Vogelaar, Iris; Goede, S Lucas; Bosch, Linda J W et al. (2018) Cost-effectiveness of High-performance Biomarker Tests vs Fecal Immunochemical Test for Noninvasive Colorectal Cancer Screening. Clin Gastroenterol Hepatol 16:504-512.e11
Naber, Steffie K; Kuntz, Karen M; Henrikson, Nora B et al. (2018) Cost Effectiveness of Age-Specific Screening Intervals for People With Family Histories of Colorectal Cancer. Gastroenterology 154:105-116.e20
Meester, Reinier G S; Doubeni, Chyke A; Zauber, Ann G et al. (2017) Impact of adenoma detection on the benefit of faecal testing vs. colonoscopy for colorectal cancer. Int J Cancer 141:2359-2367
Hubbard, Rebecca A; Johnson, Eric; Chubak, Jessica et al. (2017) Accounting for misclassification in electronic health records-derived exposures using generalized linear finite mixture models. Health Serv Outcomes Res Methodol 17:101-112
Rutter, Carolyn M; Knudsen, Amy B; Marsh, Tracey L et al. (2016) Validation of Models Used to Inform Colorectal Cancer Screening Guidelines: Accuracy and Implications. Med Decis Making 36:604-14
Meester, Reinier G S; Zauber, Ann G; Doubeni, Chyke A et al. (2016) Consequences of Increasing Time to Colonoscopy Examination After Positive Result From Fecal Colorectal Cancer Screening Test. Clin Gastroenterol Hepatol 14:1445-1451.e8
Knudsen, Amy B; Zauber, Ann G; Rutter, Carolyn M et al. (2016) Estimation of Benefits, Burden, and Harms of Colorectal Cancer Screening Strategies: Modeling Study for the US Preventive Services Task Force. JAMA 315:2595-609
Tinmouth, Jill; Lansdorp-Vogelaar, Iris; Allison, James E (2015) Faecal immunochemical tests versus guaiac faecal occult blood tests: what clinicians and colorectal cancer screening programme organisers need to know. Gut 64:1327-37
Haug, Ulrike; Knudsen, Amy B; Lansdorp-Vogelaar, Iris et al. (2015) Development of new non-invasive tests for colorectal cancer screening: the relevance of information on adenoma detection. Int J Cancer 136:2864-74
Meester, Reinier G S; Doubeni, Chyke A; Zauber, Ann G et al. (2015) Public health impact of achieving 80% colorectal cancer screening rates in the United States by 2018. Cancer 121:2281-5

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