In this application, we propose to establish a clinical center to participate as one of 15 centers in the """"""""Mortality and Morbidity in Hemodialysis Patients (MMHD): Full Scale Trial"""""""". This trial has been developed to help identify possible treatment interventions leading to a reduced rate of morbidity and mortality of patients on hemodialysis. Patients will be randomized in a two-by-two factorial clinical trial to determine whether increased delivered hemodialysis and high flux dialysis will reduce morbidity and mortality rates for this patient population.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01DK049242-02
Application #
2149904
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1994-09-30
Project End
2001-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Lankenau Hospital
Department
Type
DUNS #
City
Wynnewood
State
PA
Country
United States
Zip Code
19096
Unruh, Mark L; Newman, Anne B; Larive, Brett et al. (2008) The influence of age on changes in health-related quality of life over three years in a cohort undergoing hemodialysis. J Am Geriatr Soc 56:1608-17
Unruh, Mark; Miskulin, Dana; Yan, Guofen et al. (2004) Racial differences in health-related quality of life among hemodialysis patients. Kidney Int 65:1482-91
Unruh, Mark; Yan, Guofen; Radeva, Milena et al. (2003) Bias in assessment of health-related quality of life in a hemodialysis population: a comparison of self-administered and interviewer-administered surveys in the HEMO study. J Am Soc Nephrol 14:2132-41
Miskulin, D C; Athienites, N V; Yan, G et al. (2001) Comorbidity assessment using the Index of Coexistent Diseases in a multicenter clinical trial. Kidney Int 60:1498-510