The most common inherited disorder causing blindness in man is retinitis pigmentosa, a family of diseases in which the photoreceptor cells of the retina degenerate disappear slowly and progressively over a period of years. Similar inherited diseases are known in several laboratory animals. In the past several decades the most widely studied mutant has been the Royal College of Surgeons (RCS) rat with inherited retinal dystrophy. Four congenic strains of RCS rats are also available that either serve as genetic control animals or have different types of eye pigmentation and different rates of retinal degeneration. The goals of this proposal are 1) to maintain a breeding colony of the RCS rats and four congenic strains, 2) to maintain the congenic status of the congenic strains, and 3) to distribute animals and eye tissues to other investigators who request them. It is anticipated that increased availability of these animals will stimulate research by attracting new and established investigators to the field of inherited retinal degenerations.
| Orhan, Elise; Dalkara, Deniz; Neuillé, Marion et al. (2015) Genotypic and phenotypic characterization of P23H line 1 rat model. PLoS One 10:e0127319 |
| Vollrath, Douglas; Yasumura, Douglas; Benchorin, Gillie et al. (2015) Tyro3 Modulates Mertk-Associated Retinal Degeneration. PLoS Genet 11:e1005723 |
| Alavi, Marcel V; Chiang, Wei-Chieh; Kroeger, Heike et al. (2015) In Vivo Visualization of Endoplasmic Reticulum Stress in the Retina Using the ERAI Reporter Mouse. Invest Ophthalmol Vis Sci 56:6961-70 |
| Li, Mei; Yasumura, Douglas; Ma, Aye Aye K et al. (2013) Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease. PLoS One 8:e56026 |
| Deng, Wen-Tao; Dinculescu, Astra; Li, Qiuhong et al. (2012) Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats. Invest Ophthalmol Vis Sci 53:1895-904 |
| Kroeger, Heike; Messah, Carissa; Ahern, Kelly et al. (2012) Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration. Invest Ophthalmol Vis Sci 53:7590-9 |
| Shinde, Vishal M; Sizova, Olga S; Lin, Jonathan H et al. (2012) ER stress in retinal degeneration in S334ter Rho rats. PLoS One 7:e33266 |
| Gorbatyuk, Marina S; Gorbatyuk, Oleg S; LaVail, Matthew M et al. (2012) Functional rescue of P23H rhodopsin photoreceptors by gene delivery. Adv Exp Med Biol 723:191-7 |
| Grishanin, Ruslan N; Yang, Haidong; Liu, Xiaorong et al. (2008) Retinal TrkB receptors regulate neural development in the inner, but not outer, retina. Mol Cell Neurosci 38:431-43 |
| Pennesi, Mark E; Nishikawa, Shimpei; Matthes, Michael T et al. (2008) The relationship of photoreceptor degeneration to retinal vascular development and loss in mutant rhodopsin transgenic and RCS rats. Exp Eye Res 87:561-70 |
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