The most common inherited disorder causing blindness in man is retinitis pigmentosa, a family of diseases in which the photoreceptor cells of the retina degenerate disappear slowly and progressively over a period of years. Similar inherited diseases are known in several laboratory animals. In the past several decades the most widely studied mutant has been the Royal College of Surgeons (RCS) rat with inherited retinal dystrophy. Four congenic strains of RCS rats are also available that either serve as genetic control animals or have different types of eye pigmentation and different rates of retinal degeneration. The goals of this proposal are 1) to maintain a breeding colony of the RCS rats and four congenic strains, 2) to maintain the congenic status of the congenic strains, and 3) to distribute animals and eye tissues to other investigators who request them. It is anticipated that increased availability of these animals will stimulate research by attracting new and established investigators to the field of inherited retinal degenerations.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01EY006842-05
Application #
3551940
Study Section
Vision Research and Training Committee (VSN)
Project Start
1986-09-30
Project End
1992-03-31
Budget Start
1990-09-30
Budget End
1992-03-31
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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