Abstract

The participating cardiologists and cardiovascular surgeons from Mayo Clinic will work with the other Bypass Angioplasty Revascularization Investigation (BARI) members and NHLBI staff in a multicenter trial that will test in a prospective randomized study if percutaneous transluminal coronary angioplasty (PTCA) is associated with similar relief of angina pectoris as coronary artery bypass graft surgery (CABGS) in patients with multivessel coronary artery disease without an increased risk of death or myocardial infarction and is performed with long-term lower socioeconomic cost. This trial will also test if, in comparable patients with multivessel coronary artery disease, PTCA (even with less complete revascularization) is equal to CABGS in maintaining survival and protecting against disabling angina pectoris and myocardial infarction over a ten year follow-up. Even if PTCA is proven to be a comparable alternative revascularization procedure only for a minority of patients with ischemic heart disease who are now receiving coronary artery bypass graft surgery, potential for health care cost containment could be great.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
2U01HL038493-09
Application #
2218863
Study Section
Clinical Trials Review Committee (CLTR)
Project Start
1987-06-01
Project End
1997-11-30
Budget Start
1994-12-15
Budget End
1995-11-30
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Holmes Jr, David R; Kim, Lauren J; Brooks, Maria Mori et al. (2007) The effect of coronary artery bypass grafting on specific causes of long-term mortality in the Bypass Angioplasty Revascularization Investigation. J Thorac Cardiovasc Surg 134:38-46, 46.e1
BARI Investigators (2007) The final 10-year follow-up results from the BARI randomized trial. J Am Coll Cardiol 49:1600-6
Holper, Elizabeth M; Brooks, Maria Mori; Kim, Lauren J et al. (2007) Effects of heart failure and diabetes mellitus on long-term mortality after coronary revascularization (from the BARI Trial). Am J Cardiol 100:196-202
Kip, Kevin E; Alderman, Edwin L; Bourassa, Martial G et al. (2002) Differential influence of diabetes mellitus on increased jeopardized myocardium after initial angioplasty or bypass surgery: bypass angioplasty revascularization investigation. Circulation 105:1914-20
Schwartz, Leonard; Kip, Kevin E; Frye, Robert L et al. (2002) Coronary bypass graft patency in patients with diabetes in the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 106:2652-8
Vander Salm, Thomas J; Kip, Kevin E; Jones, Robert H et al. (2002) What constitutes optimal surgical revascularization? Answers from the Bypass Angioplasty Revascularization Investigation (BARI). J Am Coll Cardiol 39:565-72
Bittner, Vera; Hardison, Regina; Kelsey, Sheryl F et al. (2002) Non-high-density lipoprotein cholesterol levels predict five-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 106:2537-42
Gurm, Hitinder S; Whitlow, Patrick L; Kip, Kevin E et al. (2002) The impact of body mass index on short- and long-term outcomes inpatients undergoing coronary revascularization. Insights from the bypass angioplasty revascularization investigation (BARI). J Am Coll Cardiol 39:834-40
Berger, P B; Velianou, J L; Aslanidou Vlachos, H et al. (2001) Survival following coronary angioplasty versus coronary artery bypass surgery in anatomic subsets in which coronary artery bypass surgery improves survival compared with medical therapy. Results from the Bypass Angioplasty Revascularization Investigation J Am Coll Cardiol 38:1440-9
Feit, F; Brooks, M M; Sopko, G et al. (2000) Long-term clinical outcome in the Bypass Angioplasty Revascularization Investigation Registry: comparison with the randomized trial. BARI Investigators. Circulation 101:2795-802

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