Abstract

) FHS: Molecular Genetics and Genetic Epidemiology is submitted collaboratively by seven research groups including four clinical sites (University of North Carolina; Boston University; University of Minnesota; and University of Utah), a molecular biology laboratory (University of Utah), a coordinating center (Washington University, St. Louis, MO), a chemistry laboratory (University of Minnesota). The proposed study will perform state-of-the-art molecular genetic and genetic epidemiology studies using the extensive data on family and medical histories, risk factors, life style, blood specimens and banked DNA, previously collected by the Family Heart Study (FHS). The purpose is to identify and characterize genes of coronary heart disease (CHD) and atherosclerosis, familial environmental factors and behavioral characteristics, and to advance our understanding of how they interact with one another in the development of clinical outcomes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01HL056569-03
Application #
2750560
Study Section
Special Emphasis Panel (ZHL1-CSR-R (O1))
Project Start
1996-08-15
Project End
2000-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
3
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Genetics
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Lai, Lana Y H; Petrone, Andrew B; Pankow, James S et al. (2015) Lack of association of apolipoprotein E (Apo E) polymorphism with the prevalence of metabolic syndrome: the National Heart, Lung and Blood Institute Family Heart Study. Diabetes Metab Res Rev 31:582-7
Holohan, Brody; De Meyer, Tim; Batten, Kimberly et al. (2015) Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening. Aging Cell 14:669-77
Lai, Y H Lana; Petrone, Andrew B; Pankow, James S et al. (2013) Association of dietary omega-3 fatty acids with prevalence of metabolic syndrome: the National Heart, Lung, and Blood Institute Family Heart Study. Clin Nutr 32:966-9
Grove, Megan L; Yu, Bing; Cochran, Barbara J et al. (2013) Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. PLoS One 8:e68095
Rahilly-Tierney, Catherine R; Arnett, Donna K; North, Kari E et al. (2011) Apolipoprotein ?4 polymorphism does not modify the association between body mass index and high-density lipoprotein cholesterol: a cross-sectional cohort study. Lipids Health Dis 10:167
Arbeev, Konstantin G; Hunt, Steven C; Kimura, Masayuki et al. (2011) Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth. Mech Ageing Dev 132:149-53
Djoussé, Luc; Hopkins, Paul N; North, Kari E et al. (2011) Chocolate consumption is inversely associated with prevalent coronary heart disease: the National Heart, Lung, and Blood Institute Family Heart Study. Clin Nutr 30:182-7
Djoussé, Luc; Hopkins, Paul N; Arnett, Donna K et al. (2011) Chocolate consumption is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the NHLBI Family Heart Study. Clin Nutr 30:38-43
Wagenknecht, Lynne E; Divers, Jasmin; Bertoni, Alain G et al. (2011) Correlates of coronary artery calcified plaque in blacks and whites with type 2 diabetes. Ann Epidemiol 21:34-41
Neogi, Tuhina; Terkeltaub, Robert; Ellison, R Curtis et al. (2011) Serum urate is not associated with coronary artery calcification: the NHLBI Family Heart Study. J Rheumatol 38:111-7

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