GEMS (Girls health Enrichment Multi-site studies) is a unique clinical trial in which different weight gain prevention interventions are being tested in two Field Centers (FCs) for high risk, preadolescent African American girls. While the interventions differ between the two FCs, there are common measures and a collaborative data base. Phase I activities are now complete, with two of the four initially funded FCs progressing to Phase II. We propose the following specific aims for the Memphis Field Center: (1) To conduct a full-scale 2-year, randomized controlled clinical trial for weight gain prevention among high risk, preadolescent African American girls; (2) To recruit 300 African American girls and their parents/caregivers, deliver a 2-year intervention, perform common and site-specific measurements, and contribute to the collaborative database shared by Memphis and Stanford; (3) To evaluate the efficacy of the intervention on our primary endpoint body mass index (BMI) and on the secondary endpoints of dietary intake, physical activity, and psychosocial variables. Additionally, the Memphis site will evaluate the efficacy of the intervention on the site-specific endpoints of percent body fat measured by dual energy x-ray absorptiometry (DEXA) and bioelectric impedance (BIA); (4) To conduct exploratory and process evaluation analyses to identify variables that mediate outcomes; and (5) To collaborate with Stanford to perform joint analyses of the collaborative data base to address questions which neither FC could address alone.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
7U01HL062662-09
Application #
7260070
Study Section
Special Emphasis Panel (ZHL1-CSR-B (M2))
Program Officer
Pratt, Charlotte
Project Start
1999-08-01
Project End
2008-02-29
Budget Start
2006-07-01
Budget End
2008-02-29
Support Year
9
Fiscal Year
2006
Total Cost
$584,700
Indirect Cost
Name
St. Jude Children's Research Hospital
Department
Type
DUNS #
067717892
City
Memphis
State
TN
Country
United States
Zip Code
38105
Hare, Marion E; Sherrill-Mittleman, Deborah; Klesges, Robert C et al. (2012) Energy underreporting in African-American girls: a longitudinal analysis. Child Obes 8:551-60
Stockton, Michelle B; McClanahan, Barbara S; Lanctot, Jennifer Q et al. (2012) Identification of facilitators and barriers to participation in weight gain prevention research by African American girls. Contemp Clin Trials 33:38-45
Dalton, William T; Klesges, Lisa M; Sherrill-Mittleman, Deborah et al. (2011) Family context as it relates to weight-related behaviors in preadolescent African American girls. Am J Health Behav 35:269-79
Klesges, Robert C; Obarzanek, Eva; Kumanyika, Shiriki et al. (2010) The Memphis Girls' health Enrichment Multi-site Studies (GEMS): an evaluation of the efficacy of a 2-year obesity prevention program in African American girls. Arch Pediatr Adolesc Med 164:1007-14
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Klesges, Robert C; Obarzanek, Eva; Klesges, Lisa M et al. (2008) Memphis Girls health Enrichment Multi-site Studies (GEMS): Phase 2: design and baseline. Contemp Clin Trials 29:42-55
Dalton 3rd, William T; Klesges, Lisa M; Beech, Bettina M et al. (2007) Comparisons between African American girls'and parents'perceptions of girls'weight concerns and weight control behaviors. Eat Disord 15:231-46
Himes, John H; Obarzanek, Eva; Baranowski, Tom et al. (2004) Early sexual maturation, body composition, and obesity in African-American girls. Obes Res 12 Suppl:64S-72S

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