The goal of the Prevention and Early Treatment of Acute Lung Injury (PETAL) Network is to develop and conduct high-quality randomized, controlled clinical trials to prevent, treat and/or improve outcomes of patients with or at risk fo acute respiratory distress syndrome (ARDS) using a multidisciplinary and collaborative approach, and to collect biologic samples and clinical data necessary to determine the molecular phenotype of disease pathogenesis, response to therapy, and recovery. The specific objective of the Pacific Northwest Clinical Center is to participate in this clinical network in orer to expand upon the work we have done through the two previous ARDS Clinical Trials Networks since 1994. ARDS is a form of hypoxemic respiratory failure that is common, often fatal, and associated with significant sequelae that have a long lasting impact on the health and quality of life of its survivors. While previous trials of pharmacologic agents have failed to decrease mortality of patients with ARDS, the first two NHLBI ARDS Networks have demonstrated that changes in ventilator and fluid management can profoundly improve patient outcome. Since the publication of the landmark study of low tidal volume ventilation in 2000, there has been a steady drop in the case fatality of ARDS. The preceding NHLBI ARDS Networks proved the hypothesis that an investigator-directed network of clinical and research centers can design and conduct investigations that would improve outcomes for patients with ARDS. By expanding the focus beyond the ICU, this new network has the potential to be even more far- reaching. The proposed Pacific Northwest Clinical Center embodies the experienced, diverse, collaborative and multidisciplinary approach that will lead to PETAL's success. We are a team of academic and community hospitals;of critical care, trauma/surgical and emergency medicine specialists;and of clinical trialists, basic scientists;epidemiologists, clinicians, and research coordinators, in both Seattle, Washington and Portland, Oregon. We believe that the opportunity to improve care and both short and long-term outcomes of critically ill patients is in the hands of this new PETAL Network. In this application, we will demonstrate why the Pacific Northwest Clinical Center will be an important part of this new Network's success.

Public Health Relevance

We are proposing to form the Pacific Northwest Clinical Center, which will be a four-institution collaborative across Seattle, Washington and Portland, Oregon, and to join the NHLBI's Clinical Trials Network for the Prevention and Early Treatment of Acute Lung Injury. Our goal is to contribute to the selection, protocol development, conduct, quality control, analysis and dissemination of interventional studies of patients with or at risk o the acute respiratory distress syndrome, in order to improve patient-centered outcomes.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project--Cooperative Agreements (U01)
Project #
1U01HL123008-01
Application #
8705819
Study Section
Special Emphasis Panel (ZHL1-CSR-S (F1))
Program Officer
Harabin, Andrea L
Project Start
2014-06-17
Project End
2021-04-30
Budget Start
2014-06-17
Budget End
2015-04-30
Support Year
1
Fiscal Year
2014
Total Cost
$144,984
Indirect Cost
$51,143
Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Yao, Yuan; Johnson, Nicholas James; Perman, Sarah Muirhead et al. (2018) Myocardial dysfunction after out-of-hospital cardiac arrest: predictors and prognostic implications. Intern Emerg Med 13:765-772
Hsu, Cindy H; Haac, Bryce E; Drake, Mack et al. (2018) EAST Multicenter Trial on targeted temperature management for hanging-induced cardiac arrest. J Trauma Acute Care Surg 85:37-47
Huang, David T; Angus, Derek C; Moss, Marc et al. (2017) Design and Rationale of the Reevaluation of Systemic Early Neuromuscular Blockade Trial for Acute Respiratory Distress Syndrome. Ann Am Thorac Soc 14:124-133
Sjoding, Michael W; Schoenfeld, David A; Brown, Samuel M et al. (2017) Power Calculations to Select Instruments for Clinical Trial Secondary Endpoints. A Case Study of Instrument Selection for Post-Traumatic Stress Symptoms in Subjects with Acute Respiratory Distress Syndrome. Ann Am Thorac Soc 14:110-117
Sjoding, Michael W; Brown, Samuel M; Moss, Marc et al. (2017) Reply: Validity of the Posttraumatic Stress Symptoms-14 Instrument in Acute Respiratory Failure Survivors. Ann Am Thorac Soc 14:1048-1049
Brown, Samuel M; Duggal, Abhijit; Hou, Peter C et al. (2017) Nonlinear Imputation of PaO2/FIO2 From SpO2/FIO2 Among Mechanically Ventilated Patients in the ICU: A Prospective, Observational Study. Crit Care Med 45:1317-1324
Brown, Samuel M; Grissom, Colin K; Moss, Marc et al. (2016) Nonlinear Imputation of Pao2/Fio2 From Spo2/Fio2 Among Patients With Acute Respiratory Distress Syndrome. Chest 150:307-13
Benthin, Cody; Pannu, Sonal; Khan, Akram et al. (2016) The Nature and Variability of Automated Practice Alerts Derived from Electronic Health Records in a U.S. Nationwide Critical Care Research Network. Ann Am Thorac Soc 13:1784-1788