The clinical studies of the NIMH Collaborative Program on the psychobiology of depression involves an inter-related and coordinated group of investigations conducted on two samples drawn from five centers -- mood disordered probands and their relatives. This application seeks to continue the follow-up of the samples and to implement several new but related aims: 1.Investigation of the long-term course of illness in probands, relatives, spouses and controls; 2.determination of predictors of onset and recurrence in the same samples; 3.investigation of suicidal behavior, mortality and medical morbidity; 4.investigation of personality disorders i the samples, including validity, joint familial transmission with mood disorders, and input on clinical course of mood disorders; 5.a genetic linkage study of unipolar and bipolar families; 6.investigation of stability of diagnosis on familial modes of transmission; 7.further investigation of secular trends in the occurrence of mood disorders.
These aims have important public health, clinical and research implications.
| Klerman, G L; Leon, A C; Wickramaratne, P et al. (1996) The role of drug and alcohol abuse in recent increases in depression in the US. Psychol Med 26:343-51 |
| Leon, A C; Klerman, G L; Wickramaratne, P (1993) Continuing female predominance in depressive illness. Am J Public Health 83:754-7 |
| Weissman, M M; Klerman, G L (1992) Depression: current understanding and changing trends. Annu Rev Public Health 13:319-39 |
| Leon, A C; Klerman, G L; Weissman, M M et al. (1992) Evaluating the diagnostic criteria for panic disorder: measures of social morbidity as criteria. Soc Psychiatry Psychiatr Epidemiol 27:180-4 |
| Mitchell, J E; Fletcher, L; Gibeau, L et al. (1992) Shoplifting in bulimia nervosa. Compr Psychiatry 33:342-5 |
| Mitchell, J E; Pyle, R L; Hatsukami, D et al. (1991) Enema abuse as a clinical feature of bulimia nervosa. Psychosomatics 32:102-4 |
| Klerman, G L; Weissman, M M; Ouellette, R et al. (1991) Panic attacks in the community. Social morbidity and health care utilization. JAMA 265:742-6 |
| Klerman, G L (1989) Depressive disorders. Further evidence for increased medical morbidity and impairment of social functioning. Arch Gen Psychiatry 46:856-8 |
| Klerman, G L; Weissman, M M (1989) Increasing rates of depression. JAMA 261:2229-35 |
| Mirowsky, J; Ross, C E (1989) Psychiatric diagnosis as reified measurement. J Health Soc Behav 30:11-25;discussion 26-40 |
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