The clinical studies of the NIMH Collaborative Program on the psychobiology of depression involves an inter-related and coordinated group of investigations conducted on two samples drawn from five centers -- mood disordered probands and their relatives. This application seeks to continue the follow-up of the samples and to implement several new but related aims: 1.Investigation of the long-term course of illness in probands, relatives, spouses and controls; 2.determination of predictors of onset and recurrence in the same samples; 3.investigation of suicidal behavior, mortality and medical morbidity; 4.investigation of personality disorders i the samples, including validity, joint familial transmission with mood disorders, and input on clinical course of mood disorders; 5.a genetic linkage study of unipolar and bipolar families; 6.investigation of stability of diagnosis on familial modes of transmission; 7.further investigation of secular trends in the occurrence of mood disorders.
These aims have important public health, clinical and research implications.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Project--Cooperative Agreements (U01)
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Special Emphasis Panel (SRCM (C3))
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Weill Medical College of Cornell University
Schools of Medicine
New York
United States
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Klerman, G L; Leon, A C; Wickramaratne, P et al. (1996) The role of drug and alcohol abuse in recent increases in depression in the US. Psychol Med 26:343-51
Leon, A C; Klerman, G L; Wickramaratne, P (1993) Continuing female predominance in depressive illness. Am J Public Health 83:754-7
Weissman, M M; Klerman, G L (1992) Depression: current understanding and changing trends. Annu Rev Public Health 13:319-39
Leon, A C; Klerman, G L; Weissman, M M et al. (1992) Evaluating the diagnostic criteria for panic disorder: measures of social morbidity as criteria. Soc Psychiatry Psychiatr Epidemiol 27:180-4
Mitchell, J E; Fletcher, L; Gibeau, L et al. (1992) Shoplifting in bulimia nervosa. Compr Psychiatry 33:342-5
Mitchell, J E; Pyle, R L; Hatsukami, D et al. (1991) Enema abuse as a clinical feature of bulimia nervosa. Psychosomatics 32:102-4
Klerman, G L; Weissman, M M; Ouellette, R et al. (1991) Panic attacks in the community. Social morbidity and health care utilization. JAMA 265:742-6
Klerman, G L (1989) Depressive disorders. Further evidence for increased medical morbidity and impairment of social functioning. Arch Gen Psychiatry 46:856-8
Klerman, G L; Weissman, M M (1989) Increasing rates of depression. JAMA 261:2229-35
Mirowsky, J; Ross, C E (1989) Psychiatric diagnosis as reified measurement. J Health Soc Behav 30:11-25;discussion 26-40

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