Abstract

This proposal is in response to a Request for Applications concerning """"""""Diagnostic Centers for Psychiatric Linkage Studies"""""""". The overall goal of this proposal is to identify sib-pairs with Alzheimer's disease (AD), i.e., patients with AD who have siblings with symptoms of AD. It is also hoped that many of these cases will have informative family histories in relation to AD, i.e., evidence of dementia in parents and multiple other ancestors. The diagnosis of AD in the index cases will be established by contemporary research criteria. Blood samples will be obtained from sib pairs and all living individuals in large families with AD. Blood will be used for the preparation of genomic DNA and establishment of permanent lymphoblastoid cell lines at the NIMH. Although the final assessment procedures will be decided collaboratively, this proposal presents the methods that seem optimal at the present time for carrying out these activities. This application for a Diagnostic Center for Psychiatric Linkage Studies is one of three submissions from the Joint Departments of Psychiatry at Harvard Medical School. Each application focuses on a different disorder and is intended to be evaluated independently of the other two. However, if funded, these three proposals will be implemented in a coordinated fashion and, where applicable, consistency of methodology across sites will be maintained.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01MH046281-04
Application #
3553904
Study Section
Special Emphasis Panel (SRCM (10))
Project Start
1989-09-30
Project End
1994-08-31
Budget Start
1992-09-30
Budget End
1993-08-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Saad, M; Brkanac, Z; Wijsman, E M (2015) Family-based genome scan for age at onset of late-onset Alzheimer's disease in whole exome sequencing data. Genes Brain Behav 14:607-17
Hooli, Basavaraj V; Parrado, Antonio R; Mullin, Kristina et al. (2014) The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology 83:1353-8
Hooli, B V; Mohapatra, G; Mattheisen, M et al. (2012) Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology 78:1250-7
Choi, Yoonha; Marchani, Elizabeth E; Bird, Thomas D et al. (2011) Genome scan of age-at-onset in the NIMH Alzheimer disease sample uncovers multiple loci, along with evidence of both genetic and sample heterogeneity. Am J Med Genet B Neuropsychiatr Genet 156B:785-98
Blom, Elin S; Giedraitis, Vilmantas; Arepalli, Sampath et al. (2009) Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs. BMC Med Genet 10:122
Blom, Elin S; Holmans, Peter; Arepalli, Sampath et al. (2008) Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13? Am J Med Genet B Neuropsychiatr Genet 147B:778-83
Dickson, M Ryan; Li, Jian; Wiener, Howard W et al. (2008) A genomic scan for age at onset of Alzheimer's disease in 437 families from the NIMH Genetic Initiative. Am J Med Genet B Neuropsychiatr Genet 147B:784-92
Profenno, Louis A; Faraone, Stephen V (2008) Diabetes and overweight associate with non-APOE4 genotype in an Alzheimer's disease population. Am J Med Genet B Neuropsychiatr Genet 147B:822-9
De Ferrari, Giancarlo V; Papassotiropoulos, Andreas; Biechele, Travis et al. (2007) Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A 104:9434-9
Kaleem, M; Zhao, A; Hamshere, M et al. (2007) Identification of a novel valosin-containing protein polymorphism in late-onset Alzheimer's disease. Neurodegener Dis 4:376-81

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