The overall goals of this proposal are to identify the early manifestations of lung disease among the WTC workers and volunteers, as well as investigate their risk factors. To accomplish this, we will perform standardized and computer-assisted readings of all the chest CT scans performed at Mount Sinai Medical Center on these workers since January 2003, assess the findings in a systematic way, evaluate the correlation of findings with clinical, functional, and exposure indicators, and develop a protocol for continued radiological surveillance of this cohort. In order to validate the findings from the chest CT scans obtained from 2002-2011 (2870 studies in 1710 workers), we will prospectively perform paired inspiratory-expiratory, low- dose, gated CT scans and spirometry on a set of 800 participants over the 4 years of the grant, to determine the prevalence of lung cancer, emphysema, fibrotic and Interstitial lung disease, small airways disease (including air trapping). We will select individuals for whom there would not be a clinical indication to test some of the secondary hypotheses, to update a previous study, and to allow case-control studies with the retrospective cases (most of whom had respiratory symptoms, spirometric abnormalities, or chest radiographic abnormalities, or any combination thereof).

Public Health Relevance

This study will evaluate all chest CT scans performed on the former WTC workers since 2003, to investigate the manifestations of pulmonary diseases, even if subtle, and establish a method to follow these workers prospectively.

Agency
National Institute of Health (NIH)
Institute
National Institute for Occupational Safety and Health (NIOSH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01OH010401-04
Application #
8857385
Study Section
Special Emphasis Panel (ZOH1)
Program Officer
Kubale, Travis
Project Start
2012-09-01
Project End
2017-08-31
Budget Start
2015-09-01
Budget End
2017-08-31
Support Year
4
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Rojano, Belen; West, Erin; Goodman, Emily et al. (2018) Self-management behaviors in World Trade Center rescue and recovery workers with asthma. J Asthma :1-11
de la Hoz, Rafael E; Liu, Xiaoyu; Doucette, John T et al. (2018) Increased Airway Wall Thickness is Associated with Adverse Longitudinal First-Second Forced Expiratory Volume Trajectories of Former World Trade Center workers. Lung 196:481-489
de la Hoz, Rafael E; Weber, Jonathan; Xu, Dongming et al. (2018) Chest CT scan findings in World Trade Center workers. Arch Environ Occup Health :1-8
de la Hoz, Rafael E; Weissman, David N (2018) Consideration of Occupational and Environmental Lung Carcinogen Exposures for Lung Cancer Screening Using Low-Dose Chest CT. Chest 154:996-997