Abstract

The overall goal of this proposal is to characterize the WTC-related lower airway disorders, to investigate newly developed obesity-related imaging markers that may be associated with unfavorable disease expression and functional outcomes, and assess their interaction with WTC occupational exposure level. To that end, we will utilize the WTC Pulmonary Evaluation Unit Chest CT Imaging Archive, a large database with more than 3000 chest CT images on 1700 WTC workers that became operational in February 2016 and we established with our previous project. On that subcohort, we have also linked extensive datasets with disease symptoms, both pre-WTC and WTC-related occupational exposures, detailed pulmonary function and longitudinal spirometry measurements and weight trends, visual imaging classification and grading, and quantitative computer assisted method (QCAM) measurements of airway, and pulmonary parenchymal abnormalities. With our proposed research project renewal, we will continue to enrich most sources of data with periodic updates, in order to characterize the WTC-related lower airway diseases and their most important adverse prognostic risk factors, and evaluate their longitudinal trajectories.

Public Health Relevance

Utilizing an extensive amount of qualitative and quantitative imaging, clinical, and functional data, the overall goal of this study is to characterize the types of WTC-related lower airway disorders, and investigate newly developed obesity-related imaging markers that may be associated with unfavorable disease expression and functional outcomes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute for Occupational Safety and Health (NIOSH)
Type
Research Project--Cooperative Agreements (U01)
Project #
5U01OH010401-06
Application #
9526918
Study Section
Special Emphasis Panel (ZOH1)
Project Start
2017-09-01
Project End
2021-08-31
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
6
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Rojano, Belen; West, Erin; Goodman, Emily et al. (2018) Self-management behaviors in World Trade Center rescue and recovery workers with asthma. J Asthma :1-11
de la Hoz, Rafael E; Liu, Xiaoyu; Doucette, John T et al. (2018) Increased Airway Wall Thickness is Associated with Adverse Longitudinal First-Second Forced Expiratory Volume Trajectories of Former World Trade Center workers. Lung 196:481-489
de la Hoz, Rafael E; Weber, Jonathan; Xu, Dongming et al. (2018) Chest CT scan findings in World Trade Center workers. Arch Environ Occup Health :1-8
de la Hoz, Rafael E; Weissman, David N (2018) Consideration of Occupational and Environmental Lung Carcinogen Exposures for Lung Cancer Screening Using Low-Dose Chest CT. Chest 154:996-997