Abstract

The Cedar Rapids Oncology Project was funded as a CCOP in 1990 and serves a nine county area of Eastern Iowa and Western Illinois with a population base of approximately 400,000. Ninety percent of the cancer care in this region is provided by CCOP components, which see approximately 1800 new cancer patients annually. The CCOP's primary research base is NCCTG. ECOG is a secondary research base. The CCOP is a site for the STAR and SELECT studies and recently joined CTSU to access other phase III trials. The CCOP has an established structure for governance, financial management and IRB oversight. Twelve years of CCOP experience and 17 years of cooperative group experience have produced a cohesive and knowledgeable team of investigators. An experienced staff of CRA's and CRN's have been assembled. Over the past five years the CCOP has met its accrual targets, and over the last year greatly increased its cancer prevention and control accrual. Five-year statistics: treatment 422 credits and control 778 credits. Past year statistics: 88.9 treatment credits and 299 control credits. A detailed data management plan is provided and the CCOP's successful performance is documented by the accompanying research base evaluations. Efforts at ensuring minority participation are detailed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Cooperative Clinical Research--Cooperative Agreements (U10)
Project #
5U10CA052352-17
Application #
7087885
Study Section
Special Emphasis Panel (ZCA1-SRRB-E (J1))
Program Officer
Kelaghan, Joseph
Project Start
1990-09-15
Project End
2008-05-31
Budget Start
2006-06-01
Budget End
2007-05-31
Support Year
17
Fiscal Year
2006
Total Cost
$398,017
Indirect Cost

  Institution

Name
Cedar Rapids Oncology Project
Department
Type
DUNS #
186618497
City
Cedar Rapids
State
IA
Country
United States
Zip Code
52403

  Publications

Barton, Debra L; Sloan, Jeff A; Shuster, Lynne T et al. (2018) Evaluating the efficacy of vaginal dehydroepiandosterone for vaginal symptoms in postmenopausal cancer survivors: NCCTG N10C1 (Alliance). Support Care Cancer 26:643-650
Sio, Terence T; Atherton, Pamela J; Birckhead, Brandon J et al. (2016) Repeated measures analyses of dermatitis symptom evolution in breast cancer patients receiving radiotherapy in a phase 3 randomized trial of mometasone furoate vs placebo (N06C4 [alliance]). Support Care Cancer 24:3847-55
Pachman, Deirdre R; Qin, Rui; Seisler, Drew et al. (2016) Comparison of oxaliplatin and paclitaxel-induced neuropathy (Alliance A151505). Support Care Cancer 24:5059-5068
Van Loon, Katherine; Espinoza, Anne M; Fogelman, David R et al. (2014) Should combination chemotherapy serve as the backbone in clinical trials of advanced pancreatic cancer? A pooled analysis of phase II trials of gemcitabine-containing doublets plus bevacizumab. Pancreas 43:343-9
Leal, Alexis D; Qin, Rui; Atherton, Pamela J et al. (2014) North Central Cancer Treatment Group/Alliance trial N08CA-the use of glutathione for prevention of paclitaxel/carboplatin-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled study. Cancer 120:1890-7
Province, M A; Goetz, M P; Brauch, H et al. (2014) CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations. Clin Pharmacol Ther 95:216-27
Galanis, Evanthia; Anderson, S Keith; Lafky, Jackie M et al. (2013) Phase II study of bevacizumab in combination with sorafenib in recurrent glioblastoma (N0776): a north central cancer treatment group trial. Clin Cancer Res 19:4816-23
Brown, Lindsay C; Atherton, Pamela J; Neben-Wittich, Michelle A et al. (2013) Assessment of long-term rectal function in patients who received pelvic radiotherapy: a pooled North Central Cancer Treatment Group trial analysis, N09C1. Support Care Cancer 21:2869-77
Kottschade, Lisa A; Suman, Vera J; Perez, Domingo G et al. (2013) A randomized phase 2 study of temozolomide and bevacizumab or nab-paclitaxel, carboplatin, and bevacizumab in patients with unresectable stage IV melanoma : a North Central Cancer Treatment Group study, N0775. Cancer 119:586-92
Lavoie Smith, Ellen M; Barton, Debra L; Qin, Rui et al. (2013) Assessing patient-reported peripheral neuropathy: the reliability and validity of the European Organization for Research and Treatment of Cancer QLQ-CIPN20 Questionnaire. Qual Life Res 22:2787-99

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