Food Safety and Security Monitoring Project Project Summary/Abstract A primary focus of the Division of Consolidated Laboratory Services (DCLS)analytical testing is the monitoring of food products to ensure a safe supply for publicconsumption. Under this application, and in pursuit of this goal, personnel trained in theanalysis of food matrices for the detection of toxins would continue to provide analyticalsupport with sample analysis in the event of large scale food adulteration events. Inaddition, participation in ongoing matrix validation and proficiency testing by gas(GC/MS), liquid (LC/MS) and inductively coupled plasma mass spectrometry (ICP/MS)will continue to refine staff member skills and improve the laboratories abilities torespond to food emergencies. Enzyme-Linked Immunosorbent Assay analysis of foodmatrices for ricin will also be pursued, to expand our capabilities in this technique. Theanalytical expertise developed by these activities will provide the basis for theenhancement of current methodology by expanding LC/MS toxin screens to compoundsthat partition into the water phase, such as the contact herbicides diquat and paraquat.The analysis of melamine and its analogs will also be evaluated by LC/MS withautomated Solid Phase Extraction (SPE) to increase sample throughput. A further areaof study will be the investigation of Solid Phase MicroExtraction (SPME) for thedetection of polyaromatic hydrocarbons in marine tissue.
| Sheldon, Michelle T; Mistrik, Robert; Croley, Timothy R (2009) Determination of ion structures in structurally related compounds using precursor ion fingerprinting. J Am Soc Mass Spectrom 20:370-6 |
