We propose to establish a center focused on the development of field deployable physical biodosimetry utilizing EPR measurements of teeth and nails through three synergistic projects and highly integrated cores based on prior progress. The rationale for our approach we believe is compelling though relatively simple. 1. In order to respond adequately to a radiation incident in which large numbers of individuals potentially have received doses of radiation that could lead to the acute radiation syndrome it is essential to determine the dose to individuals rapidly and accurately. 2. The current capabilities and guidelines are not adequate for doing this. 3. The dosimetry system should be based on radiation induced changes within the individual so that a """"""""dosimeter"""""""" is always in place, i.e. biodosimetry is needed. 4. Biologically based biodosimetry, while potentially very valuable, inherently must have ambiguity because it depends on the activation of responses to injury that are not specific for ionizing radiation, must vary in time as the responses are developed and later attenuated, and are very likely to be affected by both pre-existing conditions and concurrent perturbations such as stress, wounds, and burns. 5. Physical biodosimetry does not have the potential limitations of the biologically based biodosimetry. 6. EPR dosimetry based on radiation-induced changes in teeth and nails is the most advanced physical biodosimetric technique and has been shown to be capable of resolving doses in the range of interest with immediate readout. 7. Our group has led the development of such EPR dosimetry and is poised to make it into a field deployable technique that can be implemented by non-expert operators without any prior training. We will complete the development of the techniques and construct field-deployable prototypes of instruments based on three different and complimentary approaches: measurements in vivo in teeth, measurements in vivo in nails, and measurements in vitro on clipped fingernails. We expect these applications to be part of a multimodality approach to field dosimetry, complementing biological biodosimetry. We have potential commercial partners, especially General Electric, who is prepared to use the prototypes to carry out rapid FDA-compliable production of fully deployable versions as soon as the prototypes are available from the proposed center.

Public Health Relevance

The development of field deployable physically based biodosimeters will provide a much-needed augmentation to the procedures available for rapid triage after a large scale event with significant radiation exposures. This capability will make it more feasible to have an effective medical response to the consequences of the radiating exposure.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-KS-I (M1))
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Macchiarini, Francesca
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Dartmouth College
Schools of Medicine
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Flood, Ann Barry; Wood, Victoria A; Schreiber, Wilson et al. (2018) Guidance to Transfer 'Bench-Ready' Medical Technology into Usual Clinical Practice: Case Study - Sensors and Spectrometer Used in EPR Oximetry. Adv Exp Med Biol 1072:233-239
Swarts, Steven G; Sidabras, Jason W; Grinberg, Oleg et al. (2018) Developments in Biodosimetry Methods for Triage With a Focus on X-band Electron Paramagnetic Resonance In Vivo Fingernail Dosimetry. Health Phys 115:140-150
Kobayashi, Kyo; Dong, Ruhong; Nicolalde, Roberto Javier et al. (2018) Development of a novel mouth model as an alternative tool to test the effectiveness of an in vivo EPR dosimetry system. Phys Med Biol 63:165002
Shirley, Ben; Li, Yanxin; Knoll, Joan H M et al. (2017) Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation. J Vis Exp :
Sholom, Sergey; McKeever, Stephen (2017) Stability of X-band EPR signals from fingernails under vacuum storage. Radiat Phys Chem Oxf Engl 1993 141:78-87
Miyake, Minoru; Nakai, Yasuhiro; Yamaguchi, Ichiro et al. (2016) IN-VIVO RADIATION DOSIMETRY USING PORTABLE L BAND EPR: ON-SITE MEASUREMENT OF VOLUNTEERS IN FUKUSHIMA PREFECTURE, JAPAN. Radiat Prot Dosimetry 172:248-253
Camarata, Andrew S; Switchenko, Jeffrey M; Demidenko, Eugene et al. (2016) Emesis as a Screening Diagnostic for Low Dose Rate (LDR) Total Body Radiation Exposure. Health Phys 110:391-4
Sholom, S; McKeever, S W S (2016) Emergency EPR dosimetry technique using vacuum-stored dry nails. Radiat Meas 88:41-47
Kobayashi, Kyo; Dong, Ruhong; Nicolalde, Roberto Javier et al. (2016) Evolution and Optimization of Tooth Models for Testing In Vivo EPR Tooth Dosimetry. Radiat Prot Dosimetry 172:152-160
Flood, Ann Barry; Ali, Arif N; Boyle, Holly K et al. (2016) Evaluating the Special Needs of The Military for Radiation Biodosimetry for Tactical Warfare Against Deployed Troops: Comparing Military to Civilian Needs for Biodosimetry Methods. Health Phys 111:169-82

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