Abstract

Our goal is to develop broad spectrum, small molecule antivirals with high barriers to resistance against multiple Priority Pathogens. We discovered a novel specific phosphoinositide (PI)-4,5-bisphosphate (PI(4,5)P2, or

Public Health Relevance

In summary, we seek to develop new classes of host-targeting antiviral therapeutics based on inhibition of Pl-4- and PIP5- kinases, and that are capable of treating multiple NIAID Emerging and Re-emerging Priority Pathogen viruses, when used alone or in combination with other available agents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109662-01
Application #
8643870
Study Section
Special Emphasis Panel (ZAI1-LR-M (J1))
Project Start
2014-04-10
Project End
2019-03-31
Budget Start
2014-04-10
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$1,425,487
Indirect Cost
$485,023

  Institution

Name
Stanford University
Department
Type
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Dudek, Amanda M; Pillay, Sirika; Puschnik, Andreas S et al. (2018) An Alternate Route for Adeno-associated Virus (AAV) Entry Independent of AAV Receptor. J Virol 92:
Gee, Marvin H; Han, Arnold; Lofgren, Shane M et al. (2018) Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes. Cell 172:549-563.e16
Barouch-Bentov, Rina; Einav, Shirit (2018) Turning Up Your Nose for a Flaviviral Encephalitis Cure. Cell Host Microbe 23:427-429
Rinis, Natalia; Golden, Jennifer E; Marceau, Caleb D et al. (2018) Editing N-Glycan Site Occupancy with Small-Molecule Oligosaccharyltransferase Inhibitors. Cell Chem Biol 25:1231-1241.e4
Constant, David A; Mateo, Roberto; Nagamine, Claude M et al. (2018) Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus. Proc Natl Acad Sci U S A 115:10136-10141
Vallania, Francesco; Tam, Andrew; Lofgren, Shane et al. (2018) Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases. Nat Commun 9:4735
Bongen, Erika; Vallania, Francesco; Utz, Paul J et al. (2018) KLRD1-expressing natural killer cells predict influenza susceptibility. Genome Med 10:45
Dovey, Cole M; Diep, Jonathan; Clarke, Bradley P et al. (2018) MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol Cell 70:936-948.e7
Pu, Szu-Yuan; Xiao, Fei; Schor, Stanford et al. (2018) Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment. Antiviral Res 155:67-75
Xiao, Fei; Wang, Stanley; Barouch-Bentov, Rina et al. (2018) Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release. MBio 9:

Showing the most recent 10 out of 73 publications