A sound study design, appropriate analytic techniques, and the proper management of data are essential components of a study to ensure that valid inferences will be made. The Biostatistics and Data Management (BDM) Core within the Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium will provide statistical and data management leadership in all phases of research including study design, development of data collection instruments, implementation of the study protocols, performance of data analyses, and the preparation of manuscripts. The BDM Core will actively collaborate in the design, conduct, and analyses of clinical research studies with the aim of conducting scientifically rigorous research and providing definitive answers to the important scientific questions described within each project-specific proposal. There are two principal objectives of the BDM Core: to provide active statistical collaboration in the design and analysis of each individual study;and to develop and maintain an integrated, centralized data management system that may be used by all studies within the URBAN ARCH Consortium. To accomplish these goals, the BDM Core will have ongoing collaboration in all aspects of the planning, execution, and evaluation of each of the URBAN ARCH Consortium projects. The BDM Core brings together a highly experienced team of investigators who have collaborated extensively in studies of alcohol use and HIV, and who have a history of international, multi-site collaboration. Within the BDM Core, a close interaction of personnel performing tasks will facilitate procedural consistency and efficiency of Consortium-wide systems. Ultimately, the BDM Core will increase the productivity of the Consortium investigators, ensure the validity and generalizability of the research findings generated from the URBAN ARCH Consortium, and elevate the scientific understanding of alcohol's impact on HIV disease outcomes.

Public Health Relevance

The Biostatistics and Data Management Core will collaborate extensively with URBAN ARCH Consortium investigators in all phases of study, from study inception to the publication of research findings. These activities will contribute to the efforts of each study to examine the consequences of alcohol on HIV disease by increasing the efficiency and productivity of Consortium investigators and ultimately ensuring the scientific integrity of results from the URBAN ARCH Consortium studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
1U24AA020779-01
Application #
8210499
Study Section
Special Emphasis Panel (ZAA1-DD (04))
Program Officer
Wang, Joe
Project Start
2011-09-15
Project End
2016-08-31
Budget Start
2011-09-15
Budget End
2012-08-31
Support Year
1
Fiscal Year
2011
Total Cost
$549,385
Indirect Cost
Name
Boston University
Department
Biostatistics & Other Math Sci
Type
Schools of Public Health
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Lorkiewicz, Sara A; Ventura, Alicia S; Heeren, Timothy C et al. (2018) Lifetime marijuana and alcohol use, and cognitive dysfunction in people with human immunodeficiency virus infection. Subst Abus 39:116-123
Kim, Theresa W; Walley, Alexander Y; Ventura, Alicia S et al. (2018) Polypharmacy and risk of falls and fractures for patients with HIV infection and substance dependence. AIDS Care 30:150-159
Forman, Leah S; Patts, Gregory J; Coleman, Sharon M et al. (2018) Use of an android phone application for automated text messages in international settings: A case study in an HIV clinical trial in St. Petersburg, Russia. Clin Trials 15:36-43
Wagman, Jennifer A; Samet, Jeffrey H; Cheng, Debbie M et al. (2018) Female Gender and HIV Transmission Risk Behaviors Among People Living with HIV Who Have Ever Used Injection Drugs in St. Petersburg, Russia. AIDS Behav 22:2830-2839
Adong, Julian; Lindan, Christina; Fatch, Robin et al. (2018) The Relationship Between Spirituality/Religiousness and Unhealthy Alcohol Use Among HIV-Infected Adults in Southwestern Uganda. AIDS Behav 22:1802-1813
Coleman, Sharon M; Gnatienko, Natalia; Lloyd-Travaglini, Christine A et al. (2018) False-positive HIV diagnoses: lessons from Ugandan and Russian research cohorts. HIV Clin Trials 19:15-22
Gnatienko, Natalia; Freiberg, Matthew S; Blokhina, Elena et al. (2018) Design of a randomized controlled trial of zinc supplementation to improve markers of mortality and HIV disease progression in HIV-positive drinkers in St. Petersburg, Russia. HIV Clin Trials 19:101-111
Saitz, Richard; Mesic, Aldina; Ventura, Alicia S et al. (2018) Alcohol Consumption and Bone Mineral Density in People with HIV and Substance Use Disorder: A Prospective Cohort Study. Alcohol Clin Exp Res :
Hahn, Judith A; Cheng, Debbie M; Emenyonu, Nneka I et al. (2018) Alcohol Use and HIV Disease Progression in an Antiretroviral Naive Cohort. J Acquir Immune Defic Syndr 77:492-501
Idrisov, Bulat; Lunze, Karsten; Cheng, Debbie M et al. (2017) Role of substance use in HIV care cascade outcomes among people who inject drugs in Russia. Addict Sci Clin Pract 12:30

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