Clinical trials to reduce heavy alcohol use in people living with HIV (PLWH) and those at high risk for HIV infection are currently being conducted through NIAAA-supported Consortia for HIV/AIDS and Alcohol-Related Outcomes Research Trials (CHAARTs). The overall objective of this proposal is to maximize the information gleaned from these trials to enable better design of evidence-based alcohol-HIV counseling interventions. While a good deal is known from the Motivational Interviewing literature about mechanisms of behavior change in counseling approaches for alcohol and other substance use, little is known about change mechanisms in interventions that focus on sexual risk behaviors or medication adherence, and there is a dearth of work on mechanisms of multiple behavior change. To address this gap, we will create a Mechanisms of Behavior Change Resource Core (MBCRC) within the Brown University Alcohol Research Center on HIV that will code provider-patient dialogues in five ongoing CHAART trials using two distinct coding systems. Specifically, we will adapt the Motivational Interviewing Skills Code to code both alcohol and HIV-relevant provider and patient language in alcohol-HIV interventions and apply the Generalized Medical Interaction Analysis System to examine factors that influence outcomes in alcohol-HIV interventions outside of motivationally-focused behavior change counseling. Overall, the MBCRC will transcribe and code provider-patient interactions across approximately 1,000 20-90, minute intervention sessions from four ongoing randomized clinical trials and one implementation study. Coding data will be used to predict future alcohol use, acceptance and use of alcohol pharmacotherapy, high-risk sex, HAART adherence, and HIV testing. Results will provide crucial insights about provider behaviors and skills that are most effective in fostering changes in drinking and HIV-relevant behaviors in identified high-risk populations, as well as key barriers to change. Results will have direct relevance (a) for training providers who work with HIV patients and those at high risk for HIV infection and (b) for the improvement and implementation of alcohol-HIV interventions in a range of contexts and populations.

Public Health Relevance

The purpose of the present study is to learn more about the kinds of provider and patient language that predict behavior change following counseling on heavy alcohol use and HIV-relevant behaviors such as HIV medication adherence and high-risk sex. Results can inform providers about the most effective methods for communicating with patients about multiple behaviors that have an important impact on the HIV epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24AA022003-02
Application #
8548212
Study Section
Special Emphasis Panel (ZAA1-DD (10))
Program Officer
Falk, Daniel
Project Start
2012-09-20
Project End
2016-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
2
Fiscal Year
2013
Total Cost
$602,902
Indirect Cost
$215,134
Name
Brown University
Department
Type
Schools of Public Health
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Sharpe, J Danielle; Zhou, Zhi; Escobar-Viera, César G et al. (2018) Interest in using mobile technology to help self-manage alcohol use among persons living with the human immunodeficiency virus: A Florida Cohort cross-sectional study. Subst Abus 39:77-82
Laws, M Barton; Magill, Molly; Mastroleo, Nadine R et al. (2018) A sequential analysis of motivational interviewing technical skills and client responses. J Subst Abuse Treat 92:27-34
Mannes, Zachary L; Hearn, Lauren E; Zhou, Zhi et al. (2018) The association between symptoms of generalized anxiety disorder and appointment adherence, overnight hospitalization, and emergency department/urgent care visits among adults living with HIV enrolled in care. J Behav Med :
Kahler, Christopher W; Pantalone, David W; Mastroleo, Nadine R et al. (2018) Motivational interviewing with personalized feedback to reduce alcohol use in HIV-infected men who have sex with men: A randomized controlled trial. J Consult Clin Psychol 86:645-656
Wang, Yan; Chen, Xinguang; Hahn, Judith A et al. (2018) Phosphatidylethanol in Comparison to Self-Reported Alcohol Consumption Among HIV-Infected Women in a Randomized Controlled Trial of Naltrexone for Reducing Hazardous Drinking. Alcohol Clin Exp Res 42:128-134
Cook, R L; Zhou, Z; Kelso-Chichetto, N E et al. (2017) Alcohol consumption patterns and HIV viral suppression among persons receiving HIV care in Florida: an observational study. Addict Sci Clin Pract 12:22
Helian, Shanjun; Brumback, Babette A; Cook, Robert L (2017) Sparse canonical correlation analysis between an alcohol biomarker and self-reported alcohol consumption. Commun Stat Simul Comput 46:7924-7941
Yao, Xue; Sun, Qiang; Liu, Wenli et al. (2016) Complete Genome Sequence of Serratia rubidaea Isolated in China. Genome Announc 4:
Cheng, Shi; Xing, Shaozhen; Zhang, Xianglilan et al. (2016) Complete Genome Sequence of a New Enterococcus faecalis Bacteriophage, vB_EfaS_IME197. Genome Announc 4:
Liu, Xiaodong; Huang, Yong; Xu, Xiaomeng et al. (2016) Complete Genome Sequence of Multidrug-Resistant Citrobacter freundii Strain P10159, Isolated from Urine Samples from a Patient with Esophageal Carcinoma. Genome Announc 4:

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