This application is a renewal of U24 AA022003 (PI, Kahler), a resource core that has been coding mechanisms of behavior change in alcohol-HIV interventions conducted by the Brown University Alcohol Research Center on HIV (ARCH) and Yale University. In this renewal, the core has been expanded to incorporate a broader range of functions and to support work being done in the Southern HIV & Alcohol Research Consortium (SHARC) and work conducted in collaboration between the Brown ARCH and SHARC. Specifically, this Behavioral Science and Biostatistics Resource Core (BSBRC) will support state-of-the-art methods for understanding the role that alcohol has on health outcomes in people living with HIV (PLWH) and for implementing and understanding effective interventions to reduce drinking, enhance engagement in HIV care, and reduce sexual risk behaviors in PLWH. Towards these ends, the BSBRC will bring together expertise in (a) the effective implementation of contingency management (CM) and motivational interventions (MI) to reduce drinking and improve related HIV outcomes, (b) the study of mechanisms of behavior change in alcohol counseling and HIV care, and (c) the use of sophisticated data analytic methods for observational and experimental data. This multidisciplinary team of experts will share intellectual resources and conduct work across geographically and racially/ethnically diverse populations to forward science on how best to address excessive alcohol use, a key contributor to HIV transmission, morbidity, and mortality in PLWH. Specific objectives of the core include: (1) to provide expertise in Contingency Management procedures and in the use of the SCRAM Continuous Alcohol Monitor biosensor, (2) to train and supervise staff on the implementation of an evidence-based MI to reduce alcohol use using high definition videoconferencing; (3) to conduct state-of- the-art, clinically relevant research on mechanisms of behavior change in alcohol interventions among PLWH including examination of the effects that videoconferencing and CM have on the therapeutic processes hypothesized in MI change theory; (4) to provide data management and biostatistical leadership and support to the SHARC U01 and, when resources permit, to other CHAART consortia. The core will contribute to the overall success of the SHARC and ARCH projects it supports while also forwarding science in intervention and statistical methodology with a particular focus on the intersection between alcohol and HIV. Thus, this resource core can make a substantial impact in reducing the burden of disease associated with excessive drinking and HIV.

Public Health Relevance

Excessive alcohol use contributes substantially to the spread of HIV and poor health outcomes in those living with HIV. By bringing together an experienced and uniquely skilled cadre of investigators, this research support core will facilitate research that examines how reductions in alcohol use improve the health of those living with HIV and elucidates the counseling techniques and motivational factors that support maintenance of these reductions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
2U24AA022003-05
Application #
9206567
Study Section
Special Emphasis Panel (ZAA1-DD (10)V)
Program Officer
Hagman, Brett Thomas
Project Start
2012-09-20
Project End
2021-08-31
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
5
Fiscal Year
2016
Total Cost
$691,840
Indirect Cost
$195,953
Name
Brown University
Department
Type
Schools of Public Health
DUNS #
001785542
City
Providence
State
RI
Country
United States
Zip Code
02912
Sharpe, J Danielle; Zhou, Zhi; Escobar-Viera, C├ęsar G et al. (2018) Interest in using mobile technology to help self-manage alcohol use among persons living with the human immunodeficiency virus: A Florida Cohort cross-sectional study. Subst Abus 39:77-82
Laws, M Barton; Magill, Molly; Mastroleo, Nadine R et al. (2018) A sequential analysis of motivational interviewing technical skills and client responses. J Subst Abuse Treat 92:27-34
Mannes, Zachary L; Hearn, Lauren E; Zhou, Zhi et al. (2018) The association between symptoms of generalized anxiety disorder and appointment adherence, overnight hospitalization, and emergency department/urgent care visits among adults living with HIV enrolled in care. J Behav Med :
Kahler, Christopher W; Pantalone, David W; Mastroleo, Nadine R et al. (2018) Motivational interviewing with personalized feedback to reduce alcohol use in HIV-infected men who have sex with men: A randomized controlled trial. J Consult Clin Psychol 86:645-656
Wang, Yan; Chen, Xinguang; Hahn, Judith A et al. (2018) Phosphatidylethanol in Comparison to Self-Reported Alcohol Consumption Among HIV-Infected Women in a Randomized Controlled Trial of Naltrexone for Reducing Hazardous Drinking. Alcohol Clin Exp Res 42:128-134
Helian, Shanjun; Brumback, Babette A; Cook, Robert L (2017) Sparse canonical correlation analysis between an alcohol biomarker and self-reported alcohol consumption. Commun Stat Simul Comput 46:7924-7941
Cook, R L; Zhou, Z; Kelso-Chichetto, N E et al. (2017) Alcohol consumption patterns and HIV viral suppression among persons receiving HIV care in Florida: an observational study. Addict Sci Clin Pract 12:22
Yao, Xue; Sun, Qiang; Liu, Wenli et al. (2016) Complete Genome Sequence of Serratia rubidaea Isolated in China. Genome Announc 4:
Cheng, Shi; Xing, Shaozhen; Zhang, Xianglilan et al. (2016) Complete Genome Sequence of a New Enterococcus faecalis Bacteriophage, vB_EfaS_IME197. Genome Announc 4:
Liu, Xiaodong; Huang, Yong; Xu, Xiaomeng et al. (2016) Complete Genome Sequence of Multidrug-Resistant Citrobacter freundii Strain P10159, Isolated from Urine Samples from a Patient with Esophageal Carcinoma. Genome Announc 4:

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