(Administrative Core): The main goal of the UC MMPC is to continue providing phenotyping services related to diabetes and its complications in numerous transgenic and knockout mouse models to investigators from all over the United States, both young and established. To achieve this goal, the UC MMPC is comprised of two phenotyping Service Cores, plus one animal care Core to coordinate issues related to the health, shipping, and husbandry of the mice. While these three Cores work extremely well together, it is the Administrative Core (Core A) that plays a pivotal role in making sure that investigators' requests are being processed and that the Service Cores are working smoothly and efficiently to provide phenotyping data to investigators. In addition, Core A is also responsible for coordinating visits by outside investigators to come to the UC MMPC to learn surgical technique or procedures. The key personnel associated with Core A have been working together closely for the last fourteen and a half years and interact on a daily basis to manage these needs of the UC MMPC. There are four specific aims for this Core:
Specific Aim 1 : To discuss and advise investigators on appropriate phenotyping services and to coordinate testing with the appropriate Service Cores.
Specific Aim 2 : To manage the data yielded by the Service Cores, provide statistical analyses, enter data into the UC MMPC and the CBU databases, and bill and collect funds generated by these data.
Specific Aim 3 : To coordinate the monthly MMPC Executive Committee Meetings, the Semi-Annual Advisory Committee Meetings, and the MMPC Seminar Series.
Specific Aim 4 : To track the acknowledgements and publications associated with the UC MMPC.

Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
20
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Type
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Rebholz, Sandra L; Melchior, John T; Davidson, W Sean et al. (2018) Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth. FASEB J 32:717-727
Shen, Ling; Liu, Yin; Tso, Patrick et al. (2018) Silencing steroid receptor coactivator-1 in the nucleus of the solitary tract reduces estrogenic effects on feeding and apolipoprotein A-IV expression. J Biol Chem 293:2091-2101
Tso, Patrick; Vurma, Mustafa; Ko, Chih-Wei et al. (2018) Effect of mono- and diglycerides on the digestion and absorption of lutein in lymph fistula rats. Am J Physiol Gastrointest Liver Physiol 315:G95-G103
Wang, Tony Y; Portincasa, Piero; Liu, Min et al. (2018) Mouse models of gallstone disease. Curr Opin Gastroenterol 34:59-70
Zhang, Ming; Sun, Kaiji; Wu, Yujun et al. (2017) Interactions between Intestinal Microbiota and Host Immune Response in Inflammatory Bowel Disease. Front Immunol 8:942
Woods, Stephen C; May, Aaron A; Liu, Min et al. (2017) Using the cerebrospinal fluid to understand ingestive behavior. Physiol Behav 178:172-178
Rao, Raghavendra; Roche, Alexander; Febres, Gerardo et al. (2017) Circulating Apolipoprotein A-IV presurgical levels are associated with improvement in insulin sensitivity after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis 13:468-473
Li, Xiaoming; Wang, Fei; Xu, Min et al. (2017) ApoA-IV improves insulin sensitivity and glucose uptake in mouse adipocytes via PI3K-Akt Signaling. Sci Rep 7:41289
Zhang, Yupeng; He, Jing; Zhao, Jing et al. (2017) Effect of ApoA4 on SERPINA3 mediated by nuclear receptors NR4A1 and NR1D1 in hepatocytes. Biochem Biophys Res Commun 487:327-332
Ma, Xiaoshi; Dai, Zhaolai; Sun, Kaiji et al. (2017) Intestinal Epithelial Cell Endoplasmic Reticulum Stress and Inflammatory Bowel Disease Pathogenesis: An Update Review. Front Immunol 8:1271

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