The Developmental Research Resource core will be led by Melissa Kemp, a systems biologist in the Department of Biomedical Engineering at Georgia Tech, and Miriam Vos, a pediatric hepatologist, in the Department of Pediatrics at Emory. Dr. Kemp is co-director of the HERCULES Systems Biology Core and is well-connected with the environmental health science community at Emory, as well as the biomedical engineering community at Georgia Tech. Dr. Vos is Director of Graduate Studies for the Nutritional Health Sciences doctoral program and a top clinical scientist at Children?s Healthcare of Atlanta. Together, Dr. Kemp and Dr. Vos will provide enthusiastic leadership to the Development Core. The core will hold a monthly chalk talk series where investigators will share their ideas with the Development Research Resource and the rest of NEALE team, including representatives of the respective offices of technology transfer. The overall theme of the core is to foster the creation of innovative technologies and approaches for use in children?s environmental health research, including development and validation of new biomarkers, informatic solutions, and devices. The core will work closely with the Targeted Research Resource, the Untargeted Research Resource, and the Biological Response Resource to test and validate new features, biomarkers, and assays. The Development Core will focus on the following objectives: Objective 1. To identify novel and innovative approaches to assess exposures and responses in children. Objective 2. To test the feasibility of these new approaches and provide rigorous validation of the methods, tests, or platforms. Objective 3. To incorporate new approaches into the CHEAR platform. The Development Core will strive to develop and incorporate the very best science into children?s health research. We will use a design charrette model to collect input from key stakeholders as we develop and adopt new methods and technologies. We will also rely on the input of our Advisory Board, which has exceptional expertise in pediatric care and children?s health research, in identifying approaches and ideas most likely to have a major impact. The above objectives will help move the creative ideas into creative solutions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Resource-Related Research Multi-Component Projects and Centers Cooperative Agreements (U2C)
Project #
1U2CES026560-01
Application #
9062180
Study Section
Special Emphasis Panel (ZES1-LWJ-J (UC))
Project Start
2015-09-30
Project End
2019-08-31
Budget Start
2015-09-01
Budget End
2016-08-31
Support Year
1
Fiscal Year
2015
Total Cost
$785,026
Indirect Cost
$175,287
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Niedzwiecki, Megan M; Samant, Pradnya; Walker, Douglas I et al. (2018) Human Suction Blister Fluid Composition Determined Using High-Resolution Metabolomics. Anal Chem 90:3786-3792
Wright, Robert O; Teitelbaum, Susan; Thompson, Claudia et al. (2018) The child health exposure analysis resource as a vehicle to measure environment in the environmental influences on child health outcomes program. Curr Opin Pediatr 30:285-291
Smirnov, Aleksandr; Jia, Wei; Walker, Douglas I et al. (2018) ADAP-GC 3.2: Graphical Software Tool for Efficient Spectral Deconvolution of Gas Chromatography-High-Resolution Mass Spectrometry Metabolomics Data. J Proteome Res 17:470-478
Chandler, Joshua D; Horati, Hamed; Walker, Douglas I et al. (2018) Determination of thiocyanate in exhaled breath condensate. Free Radic Biol Med 126:334-340
Frediani, Jennifer K; Naioti, Eric A; Vos, Miriam B et al. (2018) Arsenic exposure and risk of nonalcoholic fatty liver disease (NAFLD) among U.S. adolescents and adults: an association modified by race/ethnicity, NHANES 2005-2014. Environ Health 17:6
Hu, Xin; Chandler, Joshua D; Park, Soojin et al. (2018) Low-dose cadmium disrupts mitochondrial citric acid cycle and lipid metabolism in mouse lung. Free Radic Biol Med 131:209-217
Johnson, Caroline H; Athersuch, Toby J; Collman, Gwen W et al. (2017) Yale school of public health symposium on lifetime exposures and human health: the exposome; summary and future reflections. Hum Genomics 11:32
Wolff, Mary S; Buckley, Jessie P; Engel, Stephanie M et al. (2017) Emerging exposures of developmental toxicants. Curr Opin Pediatr 29:218-224
Uppal, Karan; Walker, Douglas I; Liu, Ken et al. (2016) Computational Metabolomics: A Framework for the Million Metabolome. Chem Res Toxicol 29:1956-1975
Jones, Dean P (2016) Hydrogen peroxide and central redox theory for aerobic life: A tribute to Helmut Sies: Scout, trailblazer, and redox pioneer. Arch Biochem Biophys 595:13-8

Showing the most recent 10 out of 11 publications