We propose to establish a Center of Excellence on childhood obesity research and training, based on a transdisciplinary systems science framework and methodologies. We propose to use systems modeling approaches with integrated application of spatial analysis. Modeling will be guided by behavioral models and basic science regarding food intake and body weight regulation to study the complex determinants of childhood obesity and the impacts of environmental and policy interventions. We will undertake epidemiological research to study the cascading influences of macrosocial environmental factors on individual-level behaviors and biology using existing and new data from large cohorts of children and their families in the U.S. and in China. In proposed projects we synthesize epidemiological methods and designs with basic sciences to explore how social, environmental and individual factors relate synergistically to energy balance related behaviors to differential epigenetic programming. We will also evaluate a novel multilevel food access intervention that can become a model of effective and sustainable community-based interventions and policy changes, focusing on an urban low-income population at high risk of obesity. By combining features of previous effective intervention approaches, within a broader systems framework, we hope to make desirable, food choices more accessible, sustainable, and cost effective. In addition, we will encourage and support developmental research to develop and evaluate environmental and policy interventions in the proposed Pilot Study Core. We will establish a computational workshop for systems modeling and GIS-based investigation (Research Resource Core and Training Core) that will provide an infrastructure to advance the Center's training and research mission. We will train a new cohort of investigators at different career stages in emerging system-science theories and methods. Over 40 well established investigators from leading US and international institutions bring transdisciplinary expertise to bear in highly relevant areas. The Center will build upon a solid research and training base with ongoing NIH funded projects directly related to childhood obesity and systems analysis.

Public Health Relevance

We propose to establish a Center of Excellence on childhood obesity research and training based on a transdisciplinary systems science framework, systems-based methodologies, and spatial analysis to study the complex etiology of childhood obesity and the impacts of environmental and policy interventions. We will establish an innovative infrastructure for related research and training, and support new pilot projects.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54HD070725-03
Application #
8481562
Study Section
Special Emphasis Panel (ZHD1-DSR-A (01))
Program Officer
Grave, Gilman D
Project Start
2011-09-22
Project End
2016-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
3
Fiscal Year
2014
Total Cost
$2,868,245
Indirect Cost
$919,852
Name
Johns Hopkins University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Ghesmaty Sangachin, Mahboobeh; Cavuoto, Lora A; Wang, Youfa (2018) Use of various obesity measurement and classification methods in occupational safety and health research: a systematic review of the literature. BMC Obes 5:28
Trude, Angela C B; Surkan, Pamela J; Cheskin, Lawrence J et al. (2018) A multilevel, multicomponent childhood obesity prevention group-randomized controlled trial improves healthier food purchasing and reduces sweet-snack consumption among low-income African-American youth. Nutr J 17:96
Min, Jungwon; Fang Yan, Alice; Wang, Youfa (2018) Mismatch in Children's Weight Assessment, Ideal Body Image, and Rapidly Increased Obesity Prevalence in China: A 10-Year, Nationwide, Longitudinal Study. Obesity (Silver Spring) 26:1777-1784
Loh, Ivory H; Schwendler, Teresa; Trude, Angela C B et al. (2018) Implementation of Text-Messaging and Social Media Strategies in a Multilevel Childhood Obesity Prevention Intervention: Process Evaluation Results. Inquiry 55:46958018779189
Min, Jungwon; Yan, Alice Fang; Wang, Vivian H C et al. (2018) Obesity, body image, and its impact on children's eating and exercise behaviors in China: A nationwide longitudinal study. Prev Med 106:101-106
Ruggiero, C F; Poirier, L; Trude, A C B et al. (2018) Implementation of B'More Healthy Communities for Kids: process evaluation of a multi-level, multi-component obesity prevention intervention. Health Educ Res 33:458-472
Perepezko, K; Tingey, L; Sato, P et al. (2018) Partnering with carryouts: implementation of a food environment intervention targeting youth obesity. Health Educ Res 33:4-13
Trude, Angela Cristina Bizzotto; Kharmats, Anna Yevgenyevna; Jones-Smith, Jessica C et al. (2018) Exposure to a multi-level multi-component childhood obesity prevention community-randomized controlled trial: patterns, determinants, and implications. Trials 19:287
Bartsch, Sarah M; Asti, Lindsey; Nyathi, Sindiso et al. (2018) Estimated Cost to a Restaurant of a Foodborne Illness Outbreak. Public Health Rep 133:274-286
Garcia, Mariana T; Sato, Priscila M; Trude, Angela C B et al. (2018) Factors Associated with Home Meal Preparation and Fast-Food Sources Use among Low-Income Urban African American Adults. Ecol Food Nutr 57:13-31

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