Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54HG003915-03S1
Application #
7499911
Study Section
Special Emphasis Panel (ZMH1-ERB-Y (02))
Program Officer
Ozenberger, Bradley
Project Start
2005-07-01
Project End
2010-06-30
Budget Start
2007-07-01
Budget End
2010-06-30
Support Year
3
Fiscal Year
2007
Total Cost
$196,875
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Napper, Andrew D; Sivendran, Sharmila (2011) Miniaturized High-Throughput Fluorescent Assay for Conversion of NAD(P)H to NAD(P). Curr Protoc Chem Biol 3:
LaFleur, Michael D; Lucumi, Edinson; Napper, Andrew D et al. (2011) Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms. J Antimicrob Chemother 66:820-6
Huang, Fei; Motlekar, Nuzhat A; Burgwin, Chelsea M et al. (2011) Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening. ACS Chem Biol 6:628-35
Napper, Andrew D; Motlekar, Nuzhat; de Almeida, Rogerio Alves et al. (2011) Parallel High-Throughput Automated Assays to Measure Cell Growth and Beta-Galactosidase Reporter Gene Expression in the Yeast Saccharomyces cerevisiae. Curr Protoc Chem Biol 3:1-14
Liu, Zhuqing; Myers, Michael C; Shah, Parag P et al. (2010) Design, synthesis and biological evaluation of a library of thiocarbazates and their activity as cysteine protease inhibitors. Comb Chem High Throughput Screen 13:337-51
Shah, Parag P; Wang, Tianhua; Kaletsky, Rachel L et al. (2010) A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells. Mol Pharmacol 78:319-24
Clifton, Justin D; Lucumi, Edinson; Myers, Michael C et al. (2010) Identification of novel inhibitors of dietary lipid absorption using zebrafish. PLoS One 5:e12386
Sivendran, Sharmila; Jones, Victoria; Sun, Dianqing et al. (2010) Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC). Bioorg Med Chem 18:896-908
Wong, E Y; Diamond, S L (2009) Advancing microarray assembly with acoustic dispensing technology. Anal Chem 81:509-14
Huryn, Donna M; Smith 3rd, Amos B (2009) The identification, characterization and optimization of small molecule probes of cysteine proteases: experiences of the Penn Center for Molecular Discovery with cathepsin B and cathepsin L. Curr Top Med Chem 9:1206-16

Showing the most recent 10 out of 21 publications