The Georgetown-Howard Universities Center for Clinical and Translational Science (GHUCCTS) is aprimary partnership of Georgetown University (GU) and Howard University (HU), with 3 affiliated hospitalsystems and research institutes: MedStar Health and Research Institute (MSH/MRI), Oak Ridge NationalLaboratory (ORNL), and the Washington, DC Veteran's Affairs Medical Center (WVAMC). This application isa resubmission of a revised previous application from 2008.
The specific aims of GHUCCTS are: 1) Tospeed improvements in human health by stimulating innovative, multidisciplinary, and cross-institutionalresearch among the GHUCCTS investigators; 2) To support the careers of clinical and translationalinvestigators through a wide variety of didactic educational programs coupled with focused mentorship; and3) To enhance clinical and translational research on underserved populations, both in the Washington DCregion and nationally, prominently including minorities, the aged, and the disabled. To accomplish theseaims, we will integrate our existing NCRR-funded programs, including two existing MOI-funded GCRCs atGU and HU and our successful multi-institutional K30 program, with a new and innovative hospital, practice-based, laboratory-based, and community-based research infrastructure for clinical and translational science.The new capabilities that we will build as part of GHUCCTS include a coordinated multi-institutionalbiomedical informatics infrastructure, an expanded clinical research operation that will create newcommunity-based clinical research units, a new community engagement resource component to support andenhance community-based research, expanded resources in regulatory knowledge and support that will beintimately integrated with ethics, and new funded research projects in the development of novel translationalmethodologies in collaboration with the supercomputing and systems genetics translational capabilities ofORNL. The integration of these clinical and translational resources across the GHUCCTS institutions will beaccompanied by a strong research education, training, and career development program that will train a newgeneration of researchers, including a new Clinical and Translational Scholars K12 program and a newMasters degree program in clinical and translational science. Our innovative approach to collaboration andmulti-disciplinary research involving multiple major research-intensive institutions of our region, incollaboration with the national CTSA network, will help our institutions and our community in the Washington,DC area benefit from the generation and application of new discoveries in clinical and translational science.
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