Program Director/Principal Investigator (Last, First, Middle): T o t O , R o b e r t D . PROJECT SUMMARY (See instmctions): The CTSA has had a major impact on the clinical and translational research (CTR) environment at UT Southwestern. Many new and highly successful programs in education and training, pilot grant awards, biomedical informatics (BMI), biostatistics, population research, community health sciences, and patient- centered outcomes research have been established. Concurrently, the CTSA stimulated UT Southwestern to invest heavily in CTR infrastructure by recruiting new clinical and translational researchers into leadership positions of major clinical departments, by creating a new research institute that focuses on stem cell biology and cancer and by greatly enhancing genomics, metabolomics, proteomics, bioinformatics, and systems biology. Two new, state-of-the art hospitals are under construction, to open in fall 2014, and they incorporate design elements that will support CTR. Our vision is to accelerate translation of new discoveries into clinical practice (T0-T4) by leveraging our scientific strengths. We will integrate and centralize our resources to work in an encouraging and collaborative research environment. Our three Specific Aims are to: 1) Enhance our Research Environment to Accelerate Translation of Discovery into Practice. We formed the Center for Translational Medicine (Center), directed by the CTSA PI, to serve as the new integrated home for our CTSA. The Center will coordinate and expand the clinical research enterprise while it educates clinical and translational researchers at every level. 2) Leverage Existinq and New Resources to Build on Four Innovative Programs in Translation including: a) Target Identification and Validation; b) Discovery in Humans; c) Intervention in Humans and d) Population Science and Community Engagement. 3) Share Knowledge and Discoverv. and Contribute to the Leadership of the National Consortium. We will share gains that are made in our programs in educational and translational research programs with the Texas Regional CTSA consortium and National CTSA Consortium. We will contribute to leadership in areas of translation including T0-T4 research, and discovery and commercialization of new drugs and devices. Our vision for accelerating CTR is well aligned with the new NCATS initiatives and takes full advantage of gains made in the previous funding. We will establish new and improved programs that will enable investigators to discover, translate and disseminate new knowledge that will improve the prevention, detection, diagnosis, and effective treatment of disease.

Public Health Relevance

Improving the health of our nation requires a concerted effort by medical scientists, health care providers and public health policymakers. This grant application will provide the crucial infrastructure necessary for medical scientists to discover and apply new diagnostics and therapeutics for the detection, prevention, detection, diagnosis and effective treatment of disease. The goal is to accelerate the movement of these new discoveries into clinical practice to improve our nation's health in a safe and effective manner.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
5UL1TR001105-05
Application #
9269634
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Talbot, Bernard
Project Start
2013-09-26
Project End
2019-04-30
Budget Start
2017-05-01
Budget End
2019-04-30
Support Year
5
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Rich, Nicole E; Hester, Caitlin; Odewole, Mobolaji et al. (2018) Racial and Ethnic Differences in Presentation and Outcomes of Hepatocellular Carcinoma. Clin Gastroenterol Hepatol :
Saade, Joanna S; Xing, Chao; Gong, Xin et al. (2018) Instability of TCF4 Triplet Repeat Expansion With Parent-Child Transmission in Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci 59:4065-4070
Gregg, L Parker; Tio, Maria Clarissa; Li, Xilong et al. (2018) Association of Monocyte Chemoattractant Protein-1 with Death and Atherosclerotic Events in Chronic Kidney Disease. Am J Nephrol 47:395-405
Khera, Rohan; Horwitz, Leora I; Lin, Zhenqiu et al. (2018) Publicly Reported Readmission Measures and the Hospital Readmissions Reduction Program: A False Equivalence? Ann Intern Med 168:670-671
Morgan, Jamie L; Kogutt, Benjamin K; Meek, Claudia et al. (2018) Pharmacokinetics of amlodipine besylate at delivery and during lactation. Pregnancy Hypertens 11:77-80
Gannavarapu, Bhavani S; Lau, Steven K M; Carter, Kristen et al. (2018) Prevalence and Survival Impact of Pretreatment Cancer-Associated Weight Loss: A Tool for Guiding Early Palliative Care. J Oncol Pract 14:e238-e250
Gregg, L Parker; Hedayati, S Susan (2018) Management of Traditional Cardiovascular Risk Factors in CKD: What Are the Data? Am J Kidney Dis 72:728-744
Li, Xiangyi; Baek, GuemHee; Ramanand, Susmita G et al. (2018) BRD4 Promotes DNA Repair and Mediates the Formation of TMPRSS2-ERG Gene Rearrangements in Prostate Cancer. Cell Rep 22:796-808
Sorkness, Ronald L; Zoratti, Edward M; Kattan, Meyer et al. (2018) Obstruction phenotype as a predictor of asthma severity and instability in children. J Allergy Clin Immunol 142:1090-1099.e4
De La Cruz-Rivera, Pamela C; Kanchwala, Mohammed; Liang, Hanquan et al. (2018) The IFN Response in Bats Displays Distinctive IFN-Stimulated Gene Expression Kinetics with Atypical RNASEL Induction. J Immunol 200:209-217

Showing the most recent 10 out of 520 publications