Program Director/Principal Investigator (Last, First, Middle): T o t O , R o b e r t D . PROJECT SUMMARY (See instmctions): The CTSA has had a major impact on the clinical and translational research (CTR) environment at UT Southwestern. Many new and highly successful programs in education and training, pilot grant awards, biomedical informatics (BMI), biostatistics, population research, community health sciences, and patient- centered outcomes research have been established. Concurrently, the CTSA stimulated UT Southwestern to invest heavily in CTR infrastructure by recruiting new clinical and translational researchers into leadership positions of major clinical departments, by creating a new research institute that focuses on stem cell biology and cancer and by greatly enhancing genomics, metabolomics, proteomics, bioinformatics, and systems biology. Two new, state-of-the art hospitals are under construction, to open in fall 2014, and they incorporate design elements that will support CTR. Our vision is to accelerate translation of new discoveries into clinical practice (T0-T4) by leveraging our scientific strengths. We will integrate and centralize our resources to work in an encouraging and collaborative research environment. Our three Specific Aims are to: 1) Enhance our Research Environment to Accelerate Translation of Discovery into Practice. We formed the Center for Translational Medicine (Center), directed by the CTSA PI, to serve as the new integrated home for our CTSA. The Center will coordinate and expand the clinical research enterprise while it educates clinical and translational researchers at every level. 2) Leverage Existinq and New Resources to Build on Four Innovative Programs in Translation including: a) Target Identification and Validation;b) Discovery in Humans;c) Intervention in Humans and d) Population Science and Community Engagement. 3) Share Knowledge and Discoverv. and Contribute to the Leadership of the National Consortium. We will share gains that are made in our programs in educational and translational research programs with the Texas Regional CTSA consortium and National CTSA Consortium. We will contribute to leadership in areas of translation including T0-T4 research, and discovery and commercialization of new drugs and devices. Our vision for accelerating CTR is well aligned with the new NCATS initiatives and takes full advantage of gains made in the previous funding. We will establish new and improved programs that will enable investigators to discover, translate and disseminate new knowledge that will improve the prevention, detection, diagnosis, and effective treatment of disease.

Public Health Relevance

Improving the health of our nation requires a concerted effort by medical scientists, health care providers and public health policymakers. This grant application will provide the crucial infrastructure necessary for medical scientists to discover and apply new diagnostics and therapeutics for the detection, prevention, detection, diagnosis and effective treatment of disease. The goal is to accelerate the movement of these new discoveries into clinical practice to improve our nation's health in a safe and effective manner.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
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Special Emphasis Panel (ZAI1-PTM-C (S2))
Program Officer
Talbot, Bernard
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University of Texas Sw Medical Center Dallas
Internal Medicine/Medicine
Schools of Medicine
United States
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Doizi, Steeve; Poindexter, John R; Pearle, Margaret S et al. (2018) Impact of Potassium Citrate vs Citric Acid on Urinary Stone Risk in Calcium Phosphate Stone Formers. J Urol 200:1278-1284
Makris, Una E; Alvarez, Carlos A; Mortensen, Eric M et al. (2018) Association of Statin Use with Increased Risk of Musculoskeletal Conditions: A Retrospective Cohort Study. Drug Saf 41:939-950
Makris, Una E; Weinreich, Mark A; Fraenkel, Liana et al. (2018) Restricting Back Pain and Subsequent Disability in Activities of Daily Living Among Community-Living Older Adults. J Aging Health 30:1482-1494
Basit, Mujeeb A; Baldwin, Krystal L; Kannan, Vaishnavi et al. (2018) Agile Acceptance Test-Driven Development of Clinical Decision Support Advisories: Feasibility of Using Open Source Software. JMIR Med Inform 6:e23
Shay, Laura A; Baldwin, Austin S; Betts, Andrea C et al. (2018) Parent-Provider Communication of HPV Vaccine Hesitancy. Pediatrics 141:
Nassour, Ibrahim; Mokdad, Ali A; Minter, Rebecca M et al. (2018) Racial and ethnic disparities in a national cohort of ampullary cancer patients. J Surg Oncol 117:220-227
Khera, Rohan; Pandey, Ambarish; Chandar, Apoorva K et al. (2018) Effects of Weight-Loss Medications on Cardiometabolic Risk Profiles: A Systematic Review and Network Meta-analysis. Gastroenterology 154:1309-1319.e7
Zhang, Song; Cao, Jing; Ahn, Chul (2018) Sample size calculation for before-after experiments with partially overlapping cohorts. Contemp Clin Trials 64:274-280
Howden, Erin J; Sarma, Satyam; Lawley, Justin S et al. (2018) Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications For Heart Failure Prevention. Circulation 137:1549-1560
Khera, Rohan; Hong, Jonathan C; Saxena, Anshul et al. (2018) Burden of Catastrophic Health Expenditures for Acute Myocardial Infarction and Stroke Among Uninsured in the United States. Circulation 137:408-410

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