The Scripps Translational Science Institute (STSI) aims to support and catalyze impactful translational and clinical research for not only the Scripps institutions, consisting of The Scripps Research Institute and Scripps Health, but also an extensive collaborating investigative network that extends from the La Jolla Mesa throughout the United States.The Scripps program combines the largest independent biomedical institute in the country with the dominant health care system in San Diego, along with an extensive partnership with the San Diego Supercomputer Center, one of the 4 national resource centers of its kind. Our areas of innovative infrastructure are informatics, genomics, and wireless medicine. Each area has a remarkably transformative potential for the future of medicine and improving the health of the public. Major advances in genomics and wireless technologies have created data torrents that were previously unimaginable, but with advanced analytical capabilities there is a remarkable opportunity to use such data to individualize medicine, defining each unique human being at multiple levels - biological, physiological, and anatomical. By individualizing medicine, there is a scientific foundation for more effective treatments, avoidance of major side effects, a far more precise means of rendering health care, and lowering of costs. Each individual's data and information can be captured with such new tools as wireless biosensors or sequencing of the entire genome. STSI has particular expertise in these tools, which includes not only gathering the data but also superior analytical capabilities. This sets up an innovative infrastructure to provide disease-agnostic resources and services for a highly productive research network - one that has dismantled the silos that previously existed of basic scientists and clinicians. Furthermore, these resources support the training and career development of the leaders of medicine for the future.
Medicine as practiced today consists of mass screening and the use of the same medications for all patients with a particular diagnosis. Our newfound ability to define the medical essence of each individual paves the way for a more efficient, safer, and less expensive form of healthcare in the future. By bringing together an exceptionally talented and productive research community, STSI will catapult this new form of medicine.
|Soragni, Elisabetta; Petrosyan, Lina; Rinkoski, Tommy A et al. (2018) Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy. Invest Ophthalmol Vis Sci 59:1888-1896|
|Saphire, Erica Ollmann; Schendel, Sharon L; Fusco, Marnie L et al. (2018) Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection. Cell 174:938-952.e13|
|Oldstone, Michael B A; Ware, Brian C; Horton, Lucy E et al. (2018) Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics. Proc Natl Acad Sci U S A 115:E7814-E7823|
|Liu, Wendy; Outlaw, Jessica J; Wineinger, Nathan et al. (2018) Effect of co-payment on behavioral response to consumer genomic testing. Transl Behav Med 8:130-136|
|Jaiswal, Stuti J; McCarthy, Thomas J; Wineinger, Nathan E et al. (2018) Melatonin and Sleep in Preventing Hospitalized Delirium: A Randomized Clinical Trial. Am J Med 131:1110-1117.e4|
|Nhu, Q M; Pockros, P J (2018) Editorial: chronic hepatitis B combination therapy-emerging success as proof-of-concept for future hepatitis B eradication? Aliment Pharmacol Ther 47:1560-1561|
|Kim, Kwang-Il; Nikzad, Nima; Quer, Giorgio et al. (2018) Real World Home Blood Pressure Variability in Over 56,000 Individuals With Nearly 17 Million Measurements. Am J Hypertens 31:566-573|
|Fisch, K M; Gamini, R; Alvarez-Garcia, O et al. (2018) Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis. Osteoarthritis Cartilage 26:1531-1538|
|Jahromi, Behnam Moein; Nhu, Quan M; Moawad, Fouad J (2018) Metastatic Cervical Cancer Causing Esophageal Compression and Dysphagia. Clin Gastroenterol Hepatol :|
|Gunn, Bronwyn M; Yu, Wen-Han; Karim, Marcus M et al. (2018) A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus. Cell Host Microbe 24:221-233.e5|
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