We have established the UCSD Clinical and Translational Research Institute (CTRI), with its hub located at the University of California, San Diego (UCSD). This regional center includes three universities (UCSD, San Diego State University and UC Riverside), 4 biomedical research institutes (Salk Institute, Sanford-Burnham Institute, J. Craig Venter Institute, and La Jolla Institute for Allergy and Immunology), and 3 academic hospitals (UCSD Medical Center, VA San Diego Medical Center and Rady Children's Hospital), one community health center (Palomar Health). The CTSA program encompasses 3 health sciences professional schools (Medicine, Pharmacy, and Nursing) and 2 Master's programs in Clinical Research and Drug Discovery Sciences. The program goals are to: 1) Develop an integrated education and training program across the translational science spectrum; 2) Empower community-based partnerships and integrate the stakeholders into translational research governance; 3) Diversify and enhance biomedical informatics infrastructure to provide a secure, confidential and inter-operative platform; 4) Provide administrative infrastructure to manage and improve clinical and translational research; and 5) Provide resources that enhance collaboration, encourage disruptive innovation and support clinical investigation. The CTSA program, which will be housed in the new Altman CTRI building, will provide the resources to develop the discipline of clinical and translational research, improve research quality and efficiency, assure a diverse workforce pipeline, and support a culture of collaboration and team science. The UCSD CTRI will incorporate UC Riverside into its TL1 program and San Diego State University Schools of Nursing and Public Health into its KL2 program to increase the diversity of disciplines and backgrounds of trainees. A new Center for Lifespan Research will support investigation across the lifespan and in special populations. Biomedical informatics expertise will be used to help manage clinical research and analyze new data, including the expanded phase I biomarker unit in the Center for Accelerating Drug Development. The UCSD CTRI will leverage its resources by collaborating with other CTSA hubs, including the consortium of UC schools (UC BRAID) and the broader CTSA network.

Public Health Relevance

The UCSD Clinical Translational Research Institute will support and transform clinical research by providing guidance and support from initial planning of research through data analysis and dissemination. It will provide an educational pipeline to train the next generation of clinical and translational scientists and involve the community in setting the direction and priorities of the organization. The CTRI will foster development of novel technologies that facilitate clinical research and support investigators by providing the services needed to conduct clinical research and improve health.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
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Special Emphasis Panel (ZTR1-SRC (99))
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Brazhnik, Olga
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University of California San Diego
Internal Medicine/Medicine
Schools of Medicine
La Jolla
United States
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Buckley, Alexandra R; Ideker, Trey; Carter, Hannah et al. (2018) Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas. Genome Med 10:69
Limjoco, Jacqueline; Thornburg, Courtney D (2018) Risk factors for cardiovascular disease in children and young adults with haemophilia. Haemophilia 24:747-754
Liu, Chao; Guo, Theresa; Xu, Guorong et al. (2018) Characterization of Alternative Splicing Events in HPV-Negative Head and Neck Squamous Cell Carcinoma Identifies an Oncogenic DOCK5 Variant. Clin Cancer Res 24:5123-5132
Sun, Heather Y; Proudfoot, James A; McCandless, Rachel T (2018) Prenatal detection of critical cardiac outflow tract anomalies remains suboptimal despite revised obstetrical imaging guidelines. Congenit Heart Dis 13:748-756
Bloss, Cinnamon S; Stoler, Justin; Schairer, Cynthia E et al. (2018) Characteristics Of Likely Precision Medicine Initiative Participants Drawn From A Large Blood Donor Population. Health Aff (Millwood) 37:786-792
Downs, Nancy; Alderman, Tracy; Bhakta, Savita et al. (2018) Implementing a college mental health program - an overview of the first twelve months. J Am Coll Health :1-5
Birmingham, Amanda; Mark, Adam M; Mazzaferro, Carlo et al. (2018) Efficient population-scale variant analysis and prioritization with VAPr. Bioinformatics 34:2843-2845
McBride, Clare; Miller-Hoover, Suzan; Proudfoot, James A (2018) A Standard Push-Pull Protocol for Waste-Free Sampling in the Pediatric Intensive Care Unit. J Infus Nurs 41:189-197
Carroll, Kate T; Bryant, Alex K; Hirshman, Brian et al. (2018) Interaction Between the Contributions of Tumor Location, Tumor Grade, and Patient Age to the Survival Benefit Associated with Gross Total Resection. World Neurosurg 111:e790-e798
Zhang, Wei; Bojorquez-Gomez, Ana; Velez, Daniel Ortiz et al. (2018) A global transcriptional network connecting noncoding mutations to changes in tumor gene expression. Nat Genet 50:613-620

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