We have established the UCSD Clinical and Translational Research Institute (CTRI), with its hub located at the University of California, San Diego (UCSD). This regional center includes three universities (UCSD, San Diego State University and UC Riverside), 4 biomedical research institutes (Salk Institute, Sanford-Burnham Institute, J. Craig Venter Institute, and La Jolla Institute for Allergy and Immunology), and 3 academic hospitals (UCSD Medical Center, VA San Diego Medical Center and Rady Children's Hospital), one community health center (Palomar Health). The CTSA program encompasses 3 health sciences professional schools (Medicine, Pharmacy, and Nursing) and 2 Master's programs in Clinical Research and Drug Discovery Sciences. The program goals are to: 1) Develop an integrated education and training program across the translational science spectrum; 2) Empower community-based partnerships and integrate the stakeholders into translational research governance; 3) Diversify and enhance biomedical informatics infrastructure to provide a secure, confidential and inter-operative platform; 4) Provide administrative infrastructure to manage and improve clinical and translational research; and 5) Provide resources that enhance collaboration, encourage disruptive innovation and support clinical investigation. The CTSA program, which will be housed in the new Altman CTRI building, will provide the resources to develop the discipline of clinical and translational research, improve research quality and efficiency, assure a diverse workforce pipeline, and support a culture of collaboration and team science. The UCSD CTRI will incorporate UC Riverside into its TL1 program and San Diego State University Schools of Nursing and Public Health into its KL2 program to increase the diversity of disciplines and backgrounds of trainees. A new Center for Lifespan Research will support investigation across the lifespan and in special populations. Biomedical informatics expertise will be used to help manage clinical research and analyze new data, including the expanded phase I biomarker unit in the Center for Accelerating Drug Development. The UCSD CTRI will leverage its resources by collaborating with other CTSA hubs, including the consortium of UC schools (UC BRAID) and the broader CTSA network.

Public Health Relevance

The UCSD Clinical Translational Research Institute will support and transform clinical research by providing guidance and support from initial planning of research through data analysis and dissemination. It will provide an educational pipeline to train the next generation of clinical and translational scientists and involve the community in setting the direction and priorities of the organization. The CTRI will foster development of novel technologies that facilitate clinical research and support investigators by providing the services needed to conduct clinical research and improve health.

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Brazhnik, Olga
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California, San Diego
Internal Medicine/Medicine
Schools of Medicine
La Jolla
United States
Zip Code
Depp, Colin A; Howland, Alex; Dumbauld, Jill et al. (2018) Development of a game-based learning tool for applied team science communication in a virtual clinical trial. J Clin Transl Sci 2:169-172
Schwimmer, Melanie H; Sawh, Mary C; Heskett, Karen M et al. (2018) A Bibliometric Analysis of Clinical and Translational Research in Pediatric Gastroenterology From 1970 to 2017. J Pediatr Gastroenterol Nutr 67:564-569
Kurnool, S; Nguyen, N H; Proudfoot, J et al. (2018) High body mass index is associated with increased risk of treatment failure and surgery in biologic-treated patients with ulcerative colitis. Aliment Pharmacol Ther 47:1472-1479
Lombardo, M V; Moon, H M; Su, J et al. (2018) Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder. Mol Psychiatry 23:1001-1013
Yu, Elizabeth L; Golshan, Shahrokh; Harlow, Kathryn E et al. (2018) Prevalence of Nonalcoholic Fatty Liver Disease in Children with Obesity. J Pediatr :
Bertrand, Kerri A; Hanan, Nathan J; Honerkamp-Smith, Gordon et al. (2018) Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk. Pediatrics 142:
Velimezi, Georgia; Robinson-Garcia, Lydia; Muñoz-Martínez, Francisco et al. (2018) Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48. Nat Commun 9:2280
Remacle, Albert G; Hullugundi, Swathi K; Dolkas, Jennifer et al. (2018) Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury. J Neuroinflammation 15:89
Proudfoot, James; Faig, Walter; Natarajan, Loki et al. (2018) A joint marginal-conditional model for multivariate longitudinal data. Stat Med 37:813-828
Schork, Nicholas J; Raghavachari, Nalini; Workshop Speakers and Participants (2018) Report: NIA workshop on translating genetic variants associated with longevity into drug targets. Geroscience 40:523-538

Showing the most recent 10 out of 146 publications