This application focuses on ethnoracial health disparities as a barrier for participation in Down syndrome research. A disproportionately higher rate of African American with Down syndrome die as young adults when compared to Whites with Down syndrome and little is known related to differences in risk for a variety of age-related diseases in Down syndrome, including Alzheimer?s disease.
The first aim of the supplement is to develop culturally and linguistically appropriate educational and recruitment materials related to research participation in Down Syndrome for African Americans with Down syndrome and their families and caregivers. The application will develop recruitment materials, evaluate community members acceptance of these materials, and refine these materials based on community feedback. These materials will target adults with Down syndrome and Alzheimer?s disease.
The second aim i s to increase recruitment of individuals with Down syndrome into related studies in the clinical trial portal Pitt+Me (https://pittplusme.org/) from diverse populations. Success will be measured by enrollment of African Americans into Down syndrome-related studies into this portal.

Public Health Relevance

The University of Pittsburgh Clinical and Translational Science Institute (CTSI) is the academic home for clinical and translational science in western Pennsylvania. Over the next 5 years, we will apply our infrastructure, training programs, best practices, and novel approaches to support translational science and scientists and to advance each of the national CTSA goals.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR001857-04S1
Application #
9988649
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Brazhnik, Olga
Project Start
2016-07-12
Project End
2021-05-31
Budget Start
2019-09-11
Budget End
2020-05-31
Support Year
4
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
Martin, Judith M; Avula, Raghunandan; Nowalk, Mary Patricia et al. (2018) Inflammatory Mediator Expression Associated With Antibody Response Induced by Live Attenuated vs Inactivated Influenza Virus Vaccine in Children. Open Forum Infect Dis 5:ofy277
Borrero, C G; Bertolet, M; Costello, J et al. (2018) Value of anterosuperior rotator cuff and labral tears at MRI for predicting long head of biceps tearing at arthroscopy. Clin Radiol 73:1058.e1-1058.e9
Matsumoto, Martha; Secrest, Aaron; Anderson, Alyce et al. (2018) Estimating the cost of skin cancer detection by dermatology providers in a large health care system. J Am Acad Dermatol 78:701-709.e1
Cheng, Jesse; Moore, Cody A; Iasella, Carlo J et al. (2018) Systematic review and meta-analysis of post-transplant lymphoproliferative disorder in lung transplant recipients. Clin Transplant 32:e13235
Christopher, Adam B; Apfel, Abraham; Sun, Tao et al. (2018) Diastolic velocity half time is associated with aortic coarctation gradient at catheterization independent of echocardiographic and clinical blood pressure gradients. Congenit Heart Dis 13:713-720
Hanrahan, Brian; Ghearing, Gena; Urban, Alexandra et al. (2018) Diagnostic accuracy of paroxysmal spells: Clinical history versus observation. Epilepsy Behav 78:73-77
Leeper, Christine M; Neal, Matthew D; McKenna, Christine et al. (2018) Principal component analysis of coagulation assays in severely injured children. Surgery 163:827-831
Hannon, Tamara S; Watson, Sara E; Jalou, Hasnaa E et al. (2018) Characteristics of Obstructive Sleep Apnea Across the Spectrum of Glucose Tolerance in Obese Adolescents. Front Endocrinol (Lausanne) 9:281
Mistry, Maanasi S; Trucco, Sara M; Maul, Timothy et al. (2018) Predictors of Poor Outcomes in Pediatric Venoarterial Extracorporeal Membrane Oxygenation. World J Pediatr Congenit Heart Surg 9:297-304
Zhou, Dong; Fu, Haiyan; Xiao, Liangxiang et al. (2018) Fibroblast-Specific ?-Catenin Signaling Dictates the Outcome of AKI. J Am Soc Nephrol 29:1257-1271

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