The pandemic caused by the SARS-CoV-2 virus continues to impact public health and the health of individuals, families, and communities. Those with a rare disease may be disproportionately affected because they may have a high risk of exposure to SARS-CoV-2 from their caregivers, housing situations, and need to attend in- person medical appointments. They may also be particularly vulnerable to complications from infection due to their underlying disease condition, immunosuppressive therapies, genetic susceptibility, and/or other factors. The scope of infection among those with rare diseases is unknown. The present proposal will investigate the sero-prevalence of immunity against SARS-CoV-2 among asymptomatic individuals with rare diseases. Specifically, this study will determine the prevalence of detectable antibodies to SARS-CoV-2 (Aim 1) and investigate the immune attributes associated with health outcomes across the life course (Aim 2) among asymptomatic individuals across the United States with one of >280 rare diseases. The anticipated results will provide crucial insights into the magnitude of the COVID-19 pandemic in the context of rare disease and will contribute to the identification of potential targets for a vaccine.

Public Health Relevance

The newly emerged SARS-CoV-2 viral pandemic has had a major impact on morbidity and mortality worldwide while causing a devastating global economic and societal impact. However, its impact on individuals with rare diseases is unknown. Knowledge about the extent of exposures and the potential humoral immunity in this population will offer insights into current and future response efforts. This study of asymptomatic individuals with a rare disease during and up to 1 year after the end of the pandemic will provide critical insights into the development of herd immunity and will identify potential targets to accelerate the discovery of a vaccine.

Agency
National Institute of Health (NIH)
Institute
National Center for Advancing Translational Sciences (NCATS)
Type
Linked Specialized Center Cooperative Agreement (UL1)
Project #
3UL1TR001857-05S2
Application #
10216856
Study Section
Program Officer
Brazhnik, Olga
Project Start
2020-09-01
Project End
2021-05-31
Budget Start
2020-09-01
Budget End
2021-05-31
Support Year
5
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15260
Martin, Judith M; Avula, Raghunandan; Nowalk, Mary Patricia et al. (2018) Inflammatory Mediator Expression Associated With Antibody Response Induced by Live Attenuated vs Inactivated Influenza Virus Vaccine in Children. Open Forum Infect Dis 5:ofy277
Borrero, C G; Bertolet, M; Costello, J et al. (2018) Value of anterosuperior rotator cuff and labral tears at MRI for predicting long head of biceps tearing at arthroscopy. Clin Radiol 73:1058.e1-1058.e9
Matsumoto, Martha; Secrest, Aaron; Anderson, Alyce et al. (2018) Estimating the cost of skin cancer detection by dermatology providers in a large health care system. J Am Acad Dermatol 78:701-709.e1
Cheng, Jesse; Moore, Cody A; Iasella, Carlo J et al. (2018) Systematic review and meta-analysis of post-transplant lymphoproliferative disorder in lung transplant recipients. Clin Transplant 32:e13235
Christopher, Adam B; Apfel, Abraham; Sun, Tao et al. (2018) Diastolic velocity half time is associated with aortic coarctation gradient at catheterization independent of echocardiographic and clinical blood pressure gradients. Congenit Heart Dis 13:713-720
Hanrahan, Brian; Ghearing, Gena; Urban, Alexandra et al. (2018) Diagnostic accuracy of paroxysmal spells: Clinical history versus observation. Epilepsy Behav 78:73-77
Leeper, Christine M; Neal, Matthew D; McKenna, Christine et al. (2018) Principal component analysis of coagulation assays in severely injured children. Surgery 163:827-831
Hannon, Tamara S; Watson, Sara E; Jalou, Hasnaa E et al. (2018) Characteristics of Obstructive Sleep Apnea Across the Spectrum of Glucose Tolerance in Obese Adolescents. Front Endocrinol (Lausanne) 9:281
Mistry, Maanasi S; Trucco, Sara M; Maul, Timothy et al. (2018) Predictors of Poor Outcomes in Pediatric Venoarterial Extracorporeal Membrane Oxygenation. World J Pediatr Congenit Heart Surg 9:297-304
Zhou, Dong; Fu, Haiyan; Xiao, Liangxiang et al. (2018) Fibroblast-Specific ?-Catenin Signaling Dictates the Outcome of AKI. J Am Soc Nephrol 29:1257-1271

Showing the most recent 10 out of 70 publications