Contact PD/PI: Buse, John B Overall Abstract Since our inception in 2008, the UNC CTSA affiliate, the North Carolina Translational and Clinical Sciences Institute (TraCS) has transformed clinical and translational science at UNC through interdisciplinary research, training, collaboration with partners and stakeholders, and strong engagement across the CTSA consortium. We have built a dynamic regional network of universities, research institutes, health care providers, and >130 community organizations across our state. In the coming funding period, we propose to add NC State University in addition to RTI International and NC A&T University as full partners in our CTSA hub. Our research infrastructure has engaged 3,234 registered members, resolved 11,147 research service requests, trained 63 faculty in our KL2 program, and supported 705 pilot grants, resulting in >$170M in external research funding, and >600 published manuscripts that have been cited >21,000 times. TraCS developed Join the Conquest, an online engagement tool to increase participation in clinical trials, that includes over 6,000 registered participants and over 200 unique research studies. The TraCS 4D Strategic Initiative and KickStart Program have facilitated 141 invention disclosures, 99 patents, 40 licenses, $57M in SBIR/STTR grants, and the creation of 68 new companies. Over the next five years, we will translate the best science from UNC and across the CTSA consortium into creative, effective, and accessible clinical and community interventions, addressing the public health problems of our state and advancing national CTSA goals by completing our Overall Aims.
Aim 1 Workforce Development: Develop and support a skilled and diverse clinical and translational research workforce to advance translational innovations and address healthcare priorities.
Aim 2 Collaboration and Engagement: Engage diverse stakeholders as active partners in translational research, and promote innovative approaches to team science.
Aim 3 Integration: Integrate translational research across the research continuum, disciplines, populations, and throughout the lifespan;
Aim 4 Methods/Processes: Develop and disseminate innovative methods and approaches to address scientific and operational barriers to translating scientific findings.
Aim 5 Informatics: Incorporate cutting-edge informatics tools and methodologies in every aspect of translational research. We believe that we have made exceptional strides in engaging our partners and our community in our activities and are well positioned to advance our mission as a public university CTSA. Going forward, we will further engage our stakeholders in the research process; train the next generation of translational researchers to flourish within interdisciplinary teams; effectively synergize clinical research with health care to identify unmet needs and implement solutions, particularly for populations at risk for poor health outcomes; and rapidly disseminate our findings to our patients, our community partners, and the CTSA Consortium. Project Summary/Abstract Page 176 Contact PD/PI: Buse, John B

Public Health Relevance

The North Carolina Translational and Clinical Sciences Institute (TraCS) is the integrated hub of the NIH Clinical and Translational Science Awards (CTSA) program at the University of North Carolina at Chapel Hill (UNC). Over the next five years, we will apply our expertise and infrastructure to support clinical and translational research, to advance health care for North Carolinians and the national goals of NCATS. Project Narrative Page 177

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Chang, Soju
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Internal Medicine/Medicine
Schools of Medicine
Chapel Hill
United States
Zip Code
Puvanesarajah, Samantha; Nyante, Sarah J; Kuzmiak, Cherie M et al. (2018) PAM50 and Risk of Recurrence Scores for Interval Breast Cancers. Cancer Prev Res (Phila) 11:327-336
Philpott, Hamish; Dellon, Evan (2018) Histologic improvement after 6 weeks of dietary elimination for eosinophilic esophagitis may be insufficient to determine efficacy. Asia Pac Allergy 8:e20
Lee, Craig R; Sriramoju, Vindhya B; Cervantes, Alexandra et al. (2018) Clinical Outcomes and Sustainability of Using CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention. Circ Genom Precis Med 11:e002069
Hibbard, Jonathan C; Friedstat, Jonathan S; Thomas, Sonia M et al. (2018) LIBERTI: A SMART study in plastic surgery. Clin Trials 15:286-293
Mock, Meredith G; Hirsch, Katie R; Blue, Malia N M et al. (2018) Post-Exercise Ingestion of Low or High Molecular Weight Glucose Polymer Solution Does Not Improve Cycle Performance in Female Athletes. J Strength Cond Res :
Peery, Anne F; Cools, Katherine S; Strassle, Paula D et al. (2018) Increasing Rates of Surgery for Patients With Nonmalignant Colorectal Polyps in the United States. Gastroenterology 154:1352-1360.e3
Buse, John B; Carlson, Anders L; Komatsu, Mitsuhisa et al. (2018) Fast-acting insulin aspart versus insulin aspart in the setting of insulin degludec-treated type 1 diabetes: Efficacy and safety from a randomized double-blind trial. Diabetes Obes Metab 20:2885-2893
Lewek, Michael D; Raiti, Cristina; Doty, Amanda (2018) The Presence of a Paretic Propulsion Reserve During Gait in Individuals Following Stroke. Neurorehabil Neural Repair 32:1011-1019
Antoniak, Silvio; Tatsumi, Kohei; Schmedes, Clare M et al. (2018) Protease-activated receptor 1 activation enhances doxorubicin-induced cardiotoxicity. J Mol Cell Cardiol 122:80-87
James, Theodore W; Crockett, Seth D (2018) Management of acute pancreatitis in the first 72 hours. Curr Opin Gastroenterol 34:330-335

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