Contact PD/PI: Buse, John B Overall Abstract Since our inception in 2008, the UNC CTSA affiliate, the North Carolina Translational and Clinical Sciences Institute (TraCS) has transformed clinical and translational science at UNC through interdisciplinary research, training, collaboration with partners and stakeholders, and strong engagement across the CTSA consortium. We have built a dynamic regional network of universities, research institutes, health care providers, and >130 community organizations across our state. In the coming funding period, we propose to add NC State University in addition to RTI International and NC A&T University as full partners in our CTSA hub. Our research infrastructure has engaged 3,234 registered members, resolved 11,147 research service requests, trained 63 faculty in our KL2 program, and supported 705 pilot grants, resulting in >$170M in external research funding, and >600 published manuscripts that have been cited >21,000 times. TraCS developed Join the Conquest, an online engagement tool to increase participation in clinical trials, that includes over 6,000 registered participants and over 200 unique research studies. The TraCS 4D Strategic Initiative and KickStart Program have facilitated 141 invention disclosures, 99 patents, 40 licenses, $57M in SBIR/STTR grants, and the creation of 68 new companies. Over the next five years, we will translate the best science from UNC and across the CTSA consortium into creative, effective, and accessible clinical and community interventions, addressing the public health problems of our state and advancing national CTSA goals by completing our Overall Aims.
Aim 1 Workforce Development: Develop and support a skilled and diverse clinical and translational research workforce to advance translational innovations and address healthcare priorities.
Aim 2 Collaboration and Engagement: Engage diverse stakeholders as active partners in translational research, and promote innovative approaches to team science.
Aim 3 Integration: Integrate translational research across the research continuum, disciplines, populations, and throughout the lifespan;
Aim 4 Methods/Processes: Develop and disseminate innovative methods and approaches to address scientific and operational barriers to translating scientific findings.
Aim 5 Informatics: Incorporate cutting-edge informatics tools and methodologies in every aspect of translational research. We believe that we have made exceptional strides in engaging our partners and our community in our activities and are well positioned to advance our mission as a public university CTSA. Going forward, we will further engage our stakeholders in the research process; train the next generation of translational researchers to flourish within interdisciplinary teams; effectively synergize clinical research with health care to identify unmet needs and implement solutions, particularly for populations at risk for poor health outcomes; and rapidly disseminate our findings to our patients, our community partners, and the CTSA Consortium. Project Summary/Abstract Page 176 Contact PD/PI: Buse, John B

Public Health Relevance

The North Carolina Translational and Clinical Sciences Institute (TraCS) is the integrated hub of the NIH Clinical and Translational Science Awards (CTSA) program at the University of North Carolina at Chapel Hill (UNC). Over the next five years, we will apply our expertise and infrastructure to support clinical and translational research, to advance health care for North Carolinians and the national goals of NCATS. Project Narrative Page 177

National Institute of Health (NIH)
National Center for Advancing Translational Sciences (NCATS)
Linked Specialized Center Cooperative Agreement (UL1)
Project #
Application #
Study Section
Special Emphasis Panel (ZTR1)
Program Officer
Chang, Soju
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Internal Medicine/Medicine
Schools of Medicine
Chapel Hill
United States
Zip Code
Peery, Anne F; Shaheen, Nicholas J; Cools, Katherine S et al. (2018) Morbidity and mortality after surgery for nonmalignant colorectal polyps. Gastrointest Endosc 87:243-250.e2
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Kinlaw, Alan C; Jonsson Funk, Michele; Conover, Mitchell M et al. (2018) Impact of New Medications and $4 Generic Programs on Overactive Bladder Treatment Among Older Adults in the United States, 2000-2015. Med Care 56:162-170
Buglak, Nicholas E; Batrakova, Elena V; Mota, Roberto et al. (2018) Insights on Localized and Systemic Delivery of Redox-Based Therapeutics. Oxid Med Cell Longev 2018:2468457
Khairat, Saif; Ottmar, Paige; Sleath, Betsy et al. (2018) Facilitating the Informed Consent Process Using Teleconsent: Protocol for a Feasibility and Efficacy Study. JMIR Res Protoc 7:e11239
Shah, Parth D; Calo, William A; Marciniak, Macary W et al. (2018) Service quality and parents' willingness to get adolescents HPV vaccine from pharmacists. Prev Med 109:106-112
Lachiewicz, Anne M; van Duin, David (2018) Reply to Elamin et al. Clin Infect Dis 67:982-983
Hailey, Claire E; Yopp, Justin M; Deal, Allison M et al. (2018) Communication with children about a parent's advanced cancer and measures of parental anxiety and depression: a cross-sectional mixed-methods study. Support Care Cancer 26:287-295
Dhatariya, Ketan; Bain, Stephen C; Buse, John B et al. (2018) The Impact of Liraglutide on Diabetes-Related Foot Ulceration and Associated Complications in Patients With Type 2 Diabetes at High Risk for Cardiovascular Events: Results From the LEADER Trial. Diabetes Care 41:2229-2235
Halladay, Jacqueline R; Lenhart, Kaitlin C; Robasky, Kimberly et al. (2018) Applicability of Precision Medicine Approaches to Managing Hypertension in Rural Populations. J Pers Med 8:

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