Abstract

: The Oswaldo Cruz Foundation (FIOCRUZ) Therapeutic and Prevention HIV/AIDS Clinical Trials Unit (FioTrials), is a multidisciplinary, integrated research center based in Rio de Janeiro, Brazil that is partnered with the Institute de Pesquisa Clinica Evandro Chagas Clinical Research Site (IPEC CRS), Together the FioTrials CTU and IPEC CRS provide care for both at-risk and HIV infected persons and cater to the needs of certain disenfranchised populations, including men who have sex with men (MSM), transgender women, racial minorities, women, and those who are poverty stricken and/or uneducated. The FioTrials CTU and IPEC CRS have unique strengths to offer the AIDS Clinical Trials Group (ACTG), HIV Prevention Trials Network (HPTN) and Microbicide Trials Network (MTN), including a cadre of leading researchers; a partnership with FIOCRUZ, an internationally-recognized governmental organization dedicated to public health research; and a participant population that compliments the scientific agendas of each network. The goal of our research is to 1) evaluate and implement integrated strategies (therapeutic and behavioral) to prevent HIV acquisition in MSM, transgender women and women; 2) evaluate the safety, efficacy and utility of rectal microbicides for our MSM population; 3) evaluate novel diagnostics, technologies, prevention and treatment interventions for tuberculosis in HIV co-infected individuals; 4) evaluate novel treatment strategies for hepatitis C, particularly for those with HI co-infection; and 5) assess novel therapeutics and improve existing HIV treatment strategies and prevent co-morbidities. Achievement of these objectives will be attributed to the outstanding infrastructure of the FioTrials CTU, its CRS and its community-focused research strategies.

Public Health Relevance

The FioTrials CTU will continue to make significant contributions to the fight against the HIV/AIDS and tuberculosis epidemics in Brazil and throughout Latin America, particularly for the population of MSM and transgender women who are the most heavily affected by the burden of HIV in Brazil.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project with Complex Structure Cooperative Agreement (UM1)
Project #
5UM1AI069476-12
Application #
9605062
Study Section
Special Emphasis Panel (ZAI1)
Program Officer
Roby, Gregg A,
Project Start
2008-01-15
Project End
2020-11-30
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
12
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
Fundacao Oswaldo Cruz
Department
Type
DUNS #
899294177
City
Rio de Janeiro
State
Country
Brazil
Zip Code
21040-360

  Publications

Barré-Sinoussi, Françoise; Abdool Karim, Salim S; Albert, Jan et al. (2018) Expert consensus statement on the science of HIV in the context of criminal law. J Int AIDS Soc 21:e25161
Costa, Jessica de Mattos; Torres, Thiago Silva; Coelho, Lara Esteves et al. (2018) Adherence to antiretroviral therapy for HIV/AIDS in Latin America and the Caribbean: Systematic review and meta-analysis. J Int AIDS Soc 21:
Jalil, Emilia M; Grinsztejn, Beatriz; Velasque, Luciane et al. (2018) Awareness, Willingness, and PrEP Eligibility Among Transgender Women in Rio de Janeiro, Brazil. J Acquir Immune Defic Syndr 79:445-452
Caro-Vega, Y; Belaunzarán-Zamudio, P F; Crabtree-Ramírez, B et al. (2018) Trends in proportion of older HIV-infected people in care in Latin America and the Caribbean: a growing challenge. Epidemiol Infect 146:1308-1311
Coelho, Lara; Rebeiro, Peter F; Castilho, Jessica L et al. (2018) Early Retention in Care Neither Mediates Nor Modifies the Effect of Sex and Sexual Mode of HIV Acquisition on HIV Survival in the Americas. AIDS Patient Care STDS 32:306-313
Caetano, Diogo Gama; Côrtes, Fernanda Heloise; Bello, Gonzalo et al. (2018) Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control. Retrovirology 15:62
Bakal, David R; Coelho, Lara E; Luz, Paula M et al. (2018) Obesity following ART initiation is common and influenced by both traditional and HIV-/ART-specific risk factors. J Antimicrob Chemother 73:2177-2185
De Boni, Raquel B; Peratikos, Meridith B; Shepherd, Bryan E et al. (2018) Is substance use associated with HIV cascade outcomes in Latin America? PLoS One 13:e0194228
Adachi, Kristina; Xu, Jiahong; Ank, Bonnie et al. (2018) Congenital CMV and HIV Perinatal Transmission. Pediatr Infect Dis J :
Ngongondo, McNeil; Miyahara, Sachiko; Hughes, Michael D et al. (2018) Hepatotoxicity During Isoniazid Preventive Therapy and Antiretroviral Therapy in People Living With HIV With Severe Immunosuppression: A Secondary Analysis of a Multi-Country Open-Label Randomized Controlled Clinical Trial. J Acquir Immune Defic Syndr 78:54-61

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