Abstract

The hepatic immune system plays important roles not only in eliminating in pathogenic microorganisms, toxins, and tumors, but also in induction of immune tolerance. The hepatic lymphocyte population is enriched in innate immune cells including macrophages (ie, Kupffer cells), natural killer T cells, and natural killer cells, which are activated during viral infection or by TLR3 ligand injection. The innate cytokine interferon-alpha is primary choice for the treatment of hepatitis B and hepatitis C infection, which affect half a billion people worldwide. This lab is interested in 1) studying the role of innate immune cells and innate cytokines in liver injury, fibrosis, regeneration, and liver tumor transformation; 2) studying liver immunology. We have demonstrated (1) that natural killer cells play important rols not only in inducing liver injury but also in inhibiting liver regeneration,(2) that IL-6 protects against T cell-mediated hepatitis via inhibition of NKT cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000368-04
Application #
7146674
Study Section
(LPS)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Gao, Bin; Radaeva, Svetlana; Park, Ogyi (2009) Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases. J Leukoc Biol 86:513-28
Jeong, Won-Il; Park, Ogyi; Gao, Bin (2008) Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology 134:248-58
Horiguchi, Norio; Wang, Lei; Mukhopadhyay, Partha et al. (2008) Cell type-dependent pro- and anti-inflammatory role of signal transducer and activator of transcription 3 in alcoholic liver injury. Gastroenterology 134:1148-58
Radaeva, Svetlana; Wang, Lei; Radaev, Sergei et al. (2007) Retinoic acid signaling sensitizes hepatic stellate cells to NK cell killing via upregulation of NK cell activating ligand RAE1. Am J Physiol Gastrointest Liver Physiol 293:G809-16
Lee, Hyun Jung; Oh, Yeo Kyoung; Rhee, Marie et al. (2007) The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS/d-GalN. J Mol Biol 369:967-84
Rajesh, Mohanraj; Pan, Hao; Mukhopadhyay, Partha et al. (2007) Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. J Leukoc Biol 82:1382-9
Batkai, Sandor; Osei-Hyiaman, Douglas; Pan, Hao et al. (2007) Cannabinoid-2 receptor mediates protection against hepatic ischemia/reperfusion injury. FASEB J 21:1788-800
Moh, Akira; Iwamoto, Yoshiki; Chai, Gui-Xuan et al. (2007) Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery. Lab Invest 87:1018-28
Cui, Yongzhi; Hosui, Atsushi; Sun, Rui et al. (2007) Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology 46:504-13
Radaeva, Svetlana; Sun, Rui; Jaruga, Barbara et al. (2006) Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners. Gastroenterology 130:435-52

Showing the most recent 10 out of 26 publications