Tau protein is was found to be elevated in the cerebrospinal fluid (CSF) of patients with Alzheimer disease (AD), reflecting neurofibrillary tangle formation. CSF tau concentrations, when combined with age in a discriminant function analysis, increased the power to maker a correct diagnosis of AD in subjects less than 70 years old. Interleukin 6 (IL-6) contributes to the interaction between immune mechanisms and brain. CSF concentrations from geriatric patients with major depression showed significantly reduced levels of both IL-6 and the soluble Il-6 receptor (sIL-6R), measured by enzyme-linked immunosorbant assays (ELISA), compared with control CSF.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000139-01
Application #
6413958
Study Section
(SBPM)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2000
Total Cost
Indirect Cost
Name
Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Rapoport, Stanley I; Schapiro, Mark B; May, Conrad (2004) Reduced brain delivery of homovanillic acid to cerebrospinal fluid during human aging. Arch Neurol 61:1721-4
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Rapoport, S I (2001) Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy. Expert Opin Investig Drugs 10:1809-18