Abstract

(1) Increased CSF concentrations of phosphotau protein, tau protein phosphorylated at threonine 231, were shown to be an effective biomarker for distinguishing patients with Alzheimer disease from age-matched controls and patients with geriatric major depression. (2): The brain is protected from edema by an intact blood-brain barrier. Damaging this barrier allows plasma salts and protein into brain, accompanied by water, with a resultant edema. This damage occurs following stroke and brain ischemia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000139-04
Application #
6814908
Study Section
(BPMS)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Rapoport, Stanley I; Schapiro, Mark B; May, Conrad (2004) Reduced brain delivery of homovanillic acid to cerebrospinal fluid during human aging. Arch Neurol 61:1721-4
Buerger, Katharina; Zinkowski, Raymond; Teipel, Stefan J et al. (2003) Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231. Am J Psychiatry 160:376-9
Tendi, Elisabetta A; Bosetti, Francesca; Dasgupta, S Fenella et al. (2002) Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells. Neurochem Res 27:319-23
Buerger, Katharina; Zinkowski, Raymond; Teipel, Stefan J et al. (2002) Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231. Arch Neurol 59:1267-72
Bosetti, Francesca; Brizzi, Francesca; Barogi, Silvia et al. (2002) Cytochrome c oxidase and mitochondrial F1F0-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease. Neurobiol Aging 23:371-6
DasGupta, S F; Rapoport, S I; Gerschenson, M et al. (2001) ATP synthesis is coupled to rat liver mitochondrial RNA synthesis. Mol Cell Biochem 221:3-10
Bosetti, F; Solaini, G; Tendi, E A et al. (2001) Mitochondrial cytochrome c oxidase subunit III is selectively down-regulated by aluminum exposure in PC12S cells. Neuroreport 12:721-4
Hampel, H; Buerger, K; Kohnken, R et al. (2001) Tracking of Alzheimer's disease progression with cerebrospinal fluid tau protein phosphorylated at threonine 231. Ann Neurol 49:545-6
Rapoport, S I (2001) Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy. Expert Opin Investig Drugs 10:1809-18