Abstract

We reviewed functional imaging and postmortem data to conclude that brain failure in Alzheimer disease occurs in two stages. The first stage is associated with reduced synaptic efficacy and reduced glucose metabolism, and is potentially reversible. The second stage, in moderate-severe dementia, is associated with neurofibrillary tangle formation, cell death and synaptic dropout, and is irreversible. The brain can be almost normally activated in the first but not the second stage. (Rapoport 2005a, b).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000148-06
Application #
7326122
Study Section
(BPMS)
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Pichika, Rama; Taha, Ameer Y; Gao, Fei et al. (2012) The synthesis and in vivo pharmacokinetics of fluorinated arachidonic acid: implications for imaging neuroinflammation. J Nucl Med 53:1383-91
Igarashi, Miki; Ma, Kaizong; Gao, Fei et al. (2011) Disturbed choline plasmalogen and phospholipid fatty acid concentrations in Alzheimer's disease prefrontal cortex. J Alzheimers Dis 24:507-17
Cunnane, Stephen; Nugent, Scott; Roy, Maggie et al. (2011) Brain fuel metabolism, aging, and Alzheimer's disease. Nutrition 27:3-20
Rapoport, Stanley I; Ramadan, Epolia; Basselin, Mireille (2011) Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. Prostaglandins Other Lipid Mediat 96:109-13
Umhau, John C; Zhou, Weiyin; Carson, Richard E et al. (2009) Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography. J Lipid Res 50:1259-68
Esposito, Giuseppe; Giovacchini, Giampiero; Der, Margaret et al. (2007) Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography. Neuroimage 34:1342-51
Alexander, Gene E; Chen, Kewei; Merkley, Tricia L et al. (2006) Regional network of magnetic resonance imaging gray matter volume in healthy aging. Neuroreport 17:951-6
Rapoport, Stanley I (2005) [In vivo imaging for evaluating synaptic integrity in Alzheimer disease] Psychol Neuropsychiatr Vieil 3:97-106
Rapoport, Stanley I (2005) In vivo approaches and rationale for quantifying kinetics and imaging brain lipid metabolic pathways. Prostaglandins Other Lipid Mediat 77:185-96
Ibanez, Vicente; Pietrini, Pietro; Furey, Maura L et al. (2004) Resting state brain glucose metabolism is not reduced in normotensive healthy men during aging, after correction for brain atrophy. Brain Res Bull 63:147-54

Showing the most recent 10 out of 24 publications