Our studies are designed to understand the interrelationships between DNA metabolism, specifically DNA damage and its repair, and the cell cycle progression in mammalian cells. We are particularly interested in characterizing the gene- and strand-specific patterns of repair of various adducts in the different phases of the cell cycle; this will allow us to correlate DNA repair processes with transcription, replication, and mutagenesis. Determination of phase-specific repair processes will also shed light on the possible accumulation and distribution of DNA damage in non-cycling (differentiated and senescent) cells.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000725-03
Application #
5200342
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code