Mutations in the insulin receptor gene are known to be a cause of some rare forms of extreme insulin resistance. The relevance of mutations in the insulin receptor gene as well as other candidate genes in the pathogenesis of the more common aging-related type II diabetes mellitus are currently unknown. Leading on from our report last year we studied two amino acid substitutions in IRS-1 in Pima indians, a minority population at risk for NIDDM. These substitutions had been associated with NIDDM in a Danish population. Neither, substitution was observed in 242 diabetic or 190 nondiabetic Pima indians. We then looked for other mutations in IRS-1.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000878-03
Application #
3745568
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code