Abstract

In this year, we have completed our labwork for stage I of a whole genome association analysis of stroke. The initial phase of this work is now published and we are embarking on a second phase, using additional samples from the Coriell repository. The initial work suggests that there are no major, common genetic loci that predisopse to ischemic stroke; however they suggest that common variability on chromosome 9 associated with heart disease and diabetes may also be a minor risk factor for ischemic stroke.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000954-06
Application #
7592082
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2007
Total Cost
$485,912
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Cheng, Yu-Ching; Stanne, Tara M; Giese, Anne-Katrin et al. (2016) Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2. Stroke 47:307-16
Bluher, A; Devan, W J; Holliday, E G et al. (2015) Heritability of young- and old-onset ischaemic stroke. Eur J Neurol 22:1488-91
Carty, Cara L; Keene, Keith L; Cheng, Yu-Ching et al. (2015) Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. Stroke 46:2063-8
Auer, Paul L; Nalls, Mike; Meschia, James F et al. (2015) Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. JAMA Neurol 72:781-8
Malik, Rainer; Freilinger, Tobias; Winsvold, Bendik S et al. (2015) Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants. Neurology 84:2132-45
Ibrahim-Verbaas, Carla A; Fornage, Myriam; Bis, Joshua C et al. (2014) Predicting stroke through genetic risk functions: the CHARGE Risk Score Project. Stroke 45:403-12
Kim, Daniel Seung; Crosslin, David R; Auer, Paul L et al. (2014) Rare coding variation in paraoxonase-1 is associated with ischemic stroke in the NHLBI Exome Sequencing Project. J Lipid Res 55:1173-8
Dichgans, Martin; Malik, Rainer; König, Inke R et al. (2014) Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke 45:24-36
Traylor, Matthew; Mäkelä, Kari-Matti; Kilarski, Laura L et al. (2014) A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. PLoS Genet 10:e1004469
Ay, Hakan; Arsava, Ethem Murat; Andsberg, Gunnar et al. (2014) Pathogenic ischemic stroke phenotypes in the NINDS-stroke genetics network. Stroke 45:3589-96

Showing the most recent 10 out of 34 publications